FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019043258> ?p ?o ?g. }

• W2019043258 endingPage "979" @default.
• W2019043258 startingPage "973" @default.
• W2019043258 abstract "Abstract Inhalation of coal dust has been shown to produce pneumoconiosis and chronic obstructive bronchopneumopathy. The active compounds responsible for these diseases have not yet been identified. We postulate that coal dust induced lung injury could be related to exposures of coal workers to aerosols capable of producing reactive oxygen species (ROS) in the lung. In this study, we investigated whether coal dusts could produce ROS in aqueous medium and the biological significance of ROS production. We found that filtrates of coal dusts are capable of oxidizing formate anion in the presence of H2O2 or O2 and are able to suppress the elastase inhibitory activity of alpha-1-antitrypsin (α1-AT). To further confirm the role of FeSO4 in coal dust induced lung injury, we also examined the pulmonary response of guinea pigs exposed to coal dust or carbon black enriched with FeSO4. Guinea pigs (N = 6/group) were exposed to filtered air, 5 mg/m3 of pulverized Illinois #6 coal (COAL), FeSO4 enriched Illinois #6 coal (COAL+Fe, 5% FeSO4 · 7H2O by weight), Illinois #6 coal wetted in distilled deionized water (WETTED COAL), Illinois #6 coal washed twice with distilled deionized water (WASHED COAL), carbon black (CARBON), or FeSO4 enriched carbon (CARBON+Fe, 5% FeSO4 · 7H2O by weight) for 3 hours, and killed 24 hours after the end of the exposure. There was no change in lactate dehydrogenase activity in any of the exposure groups except in animals exposed to COAL. There was also no change in protein concentration of lavage fluid or the viability of lavage cells in all exposure conditions. In contrast, COAL+Fe induced a decrease in the phagocytic activities (-17.4%) of macrophages, while COAL itself had no effect. Similarly, CARBON has no effect on phagocytosis while CARBON+Fe significantly depressed phagocytosis (-22.5%). Influx of neutrophils only occurred in animals exposed to CARBON+Fe. The concentration of ROS in the macrophages of animals exposed to the COAL+Fe was significantly decreased by 30.8 percent while a significant increase of ROS (27.8%) was observed in animals exposed to CARBON+Fe. WETTED-COAL generally had similar effects as that of COAL+Fe while WASHED-COAL produced no change as compared to controls. These results clearly show that FeSO4 enrichment enhances the pulmonary response of guinea pigs to coal dust exposure." @default.
• W2019043258 created "2016-06-24" @default.
• W2019043258 creator A5005021251 @default.
• W2019043258 creator A5019924950 @default.
• W2019043258 creator A5030354203 @default.
• W2019043258 creator A5073097309 @default.
• W2019043258 creator A5081279781 @default.
• W2019043258 creator A5089225268 @default.
• W2019043258 date "1996-07-01" @default.
• W2019043258 modified "2023-10-01" @default.
• W2019043258 title "The Role of Ferrous Sulfate in Coal Dust Induced Lung Injury" @default.
• W2019043258 cites W1975672902 @default.
• W2019043258 cites W1988788508 @default.
• W2019043258 cites W2005432258 @default.
• W2019043258 cites W2012921569 @default.
• W2019043258 cites W2013199019 @default.
• W2019043258 cites W2017365364 @default.
• W2019043258 cites W2018384693 @default.
• W2019043258 cites W2034933587 @default.
• W2019043258 cites W2041752231 @default.
• W2019043258 cites W2048966030 @default.
• W2019043258 cites W2059102720 @default.
• W2019043258 cites W2076022778 @default.
• W2019043258 cites W2079708232 @default.
• W2019043258 cites W2095172881 @default.
• W2019043258 cites W2279481251 @default.
• W2019043258 cites W4244080090 @default.
• W2019043258 doi "https://doi.org/10.1080/1047322x.1996.10389999" @default.
• W2019043258 hasPublicationYear "1996" @default.
• W2019043258 type Work @default.
• W2019043258 sameAs 2019043258 @default.
• W2019043258 citedByCount "2" @default.
• W2019043258 countsByYear W20190432582019 @default.
• W2019043258 crossrefType "journal-article" @default.
• W2019043258 hasAuthorship W2019043258A5005021251 @default.
• W2019043258 hasAuthorship W2019043258A5019924950 @default.
• W2019043258 hasAuthorship W2019043258A5030354203 @default.
• W2019043258 hasAuthorship W2019043258A5073097309 @default.
• W2019043258 hasAuthorship W2019043258A5081279781 @default.
• W2019043258 hasAuthorship W2019043258A5089225268 @default.
• W2019043258 hasConcept C105702510 @default.
• W2019043258 hasConcept C107872376 @default.
• W2019043258 hasConcept C127413603 @default.
• W2019043258 hasConcept C142724271 @default.
• W2019043258 hasConcept C178790620 @default.
• W2019043258 hasConcept C185592680 @default.
• W2019043258 hasConcept C2776674678 @default.
• W2019043258 hasConcept C2776715762 @default.
• W2019043258 hasConcept C2776954882 @default.
• W2019043258 hasConcept C2779429693 @default.
• W2019043258 hasConcept C43617362 @default.
• W2019043258 hasConcept C518851703 @default.
• W2019043258 hasConcept C548081761 @default.
• W2019043258 hasConcept C71924100 @default.
• W2019043258 hasConcept C86803240 @default.
• W2019043258 hasConceptScore W2019043258C105702510 @default.
• W2019043258 hasConceptScore W2019043258C107872376 @default.
• W2019043258 hasConceptScore W2019043258C127413603 @default.
• W2019043258 hasConceptScore W2019043258C142724271 @default.
• W2019043258 hasConceptScore W2019043258C178790620 @default.
• W2019043258 hasConceptScore W2019043258C185592680 @default.
• W2019043258 hasConceptScore W2019043258C2776674678 @default.
• W2019043258 hasConceptScore W2019043258C2776715762 @default.
• W2019043258 hasConceptScore W2019043258C2776954882 @default.
• W2019043258 hasConceptScore W2019043258C2779429693 @default.
• W2019043258 hasConceptScore W2019043258C43617362 @default.
• W2019043258 hasConceptScore W2019043258C518851703 @default.
• W2019043258 hasConceptScore W2019043258C548081761 @default.
• W2019043258 hasConceptScore W2019043258C71924100 @default.
• W2019043258 hasConceptScore W2019043258C86803240 @default.
• W2019043258 hasIssue "7" @default.
• W2019043258 hasLocation W20190432581 @default.
• W2019043258 hasOpenAccess W2019043258 @default.
• W2019043258 hasPrimaryLocation W20190432581 @default.
• W2019043258 hasRelatedWork W1890827738 @default.
• W2019043258 hasRelatedWork W1972813417 @default.
• W2019043258 hasRelatedWork W1983374553 @default.
• W2019043258 hasRelatedWork W2052012211 @default.
• W2019043258 hasRelatedWork W2065960757 @default.
• W2019043258 hasRelatedWork W2165238447 @default.
• W2019043258 hasRelatedWork W2415660957 @default.
• W2019043258 hasRelatedWork W2980870390 @default.
• W2019043258 hasRelatedWork W3047452253 @default.
• W2019043258 hasRelatedWork W4283823427 @default.
• W2019043258 hasVolume "11" @default.
• W2019043258 isParatext "false" @default.
• W2019043258 isRetracted "false" @default.
• W2019043258 magId "2019043258" @default.
• W2019043258 workType "article" @default.