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- W2019050809 endingPage "1188" @default.
- W2019050809 startingPage "1184" @default.
- W2019050809 abstract "Abstract In a variety of stimulated cells, platelet‐activating factor (PAF) and numerous arachidonate derivatives are coproducts that form as a consequence of receptor‐mediated phospholipid mobilization. These lipid co‐products produce a plethora of biological effects in a wide variety of cell systems. Furthermore, they often have a fascinating, although less widely appreciated, interaction. 5‐HETE, at submicromolar concentrations, exerts relatively few direct bioactions. It does, however, potently (16–160 nM) raise cytosolic free calcium [Ca 2+ ] i and augment PAF‐induced responses in human polymorphonuclear neutrophils (PMN) by as much as 100‐ to 1000‐fold. 5‐HETE acts on PMN by a structurally specific, stereospecific and pertussis toxin‐inhibitable mechanism. In addition, PMN exposed to 5‐HETE exhibit homologous but not heterologous desensitization. These findings suggest that 5‐HETE, like PAF, may bind to its own specific plasmalemmal receptors to exert its unique set of bioactions. However, further investigation is required to demonstrate any putative 5‐HETE receptors. Other potential mechanisms of 5‐HETE‐induced bioactions together with the possible effects of 5‐HETE on PAF transduction mechanisms are also discussed." @default.
- W2019050809 created "2016-06-24" @default.
- W2019050809 creator A5016151265 @default.
- W2019050809 creator A5018504950 @default.
- W2019050809 date "1991-12-01" @default.
- W2019050809 modified "2023-09-29" @default.
- W2019050809 title "Bioactions of 5-hydroxyicosatetraenoate and its interaction with platelet-activating factor" @default.
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