FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019054427> ?p ?o ?g. }

• W2019054427 endingPage "8063" @default.
• W2019054427 startingPage "8059" @default.
• W2019054427 abstract "To generate a potent cell-mediated immune response, at least two signals are required by T cells. One is engagement of the T-cell receptor with peptide-bearing major histocompatibility complex molecules. The other signal can be delivered by various molecules on the antigen-presenting cell, such as B7-1 (CD80). Many tumor cells escape immune recognition by failing to express these costimulatory molecules. Transfection of the B7 gene into some murine tumor cells allows for immune recognition and subsequent rejection of the parental tumor. We have studied an alternative approach for the introduction of B7-1 onto the surface of tumor cells. This method involves purified glycosyl-phosphatidylinositol (GPI)-anchored proteins which can spontaneously incorporate their lipid tail into cell membranes. We have created and purified a GPI-anchored B7-1 molecule (called GPI-B7) which is able to bind its cognate ligand, CD28, and incorporate itself into tumor cell membranes after a short incubation. Tumor cells that have been reconstituted with GPI-B7 can provide the costimulatory signal needed to stimulate T cells. These findings suggest an approach for the introduction of new proteins onto cell membranes to create an effective tumor vaccine for potential use in human immunotherapy." @default.
• W2019054427 created "2016-06-24" @default.
• W2019054427 creator A5006657863 @default.
• W2019054427 creator A5026676118 @default.
• W2019054427 creator A5046239561 @default.
• W2019054427 creator A5073494284 @default.
• W2019054427 creator A5083514131 @default.
• W2019054427 date "1995-08-15" @default.
• W2019054427 modified "2023-09-27" @default.
• W2019054427 title "Construction, purification, and functional incorporation on tumor cells of glycolipid-anchored human B7-1 (CD80)." @default.
• W2019054427 cites W1444462873 @default.
• W2019054427 cites W1490870966 @default.
• W2019054427 cites W1516427744 @default.
• W2019054427 cites W1526174013 @default.
• W2019054427 cites W1540720278 @default.
• W2019054427 cites W1562057469 @default.
• W2019054427 cites W1563877435 @default.
• W2019054427 cites W1664890614 @default.
• W2019054427 cites W1795738503 @default.
• W2019054427 cites W189181064 @default.
• W2019054427 cites W1954929088 @default.
• W2019054427 cites W1971869048 @default.
• W2019054427 cites W1977044110 @default.
• W2019054427 cites W1978416272 @default.
• W2019054427 cites W1986769934 @default.
• W2019054427 cites W1989270381 @default.
• W2019054427 cites W1998591058 @default.
• W2019054427 cites W2005265799 @default.
• W2019054427 cites W2007035782 @default.
• W2019054427 cites W2023235169 @default.
• W2019054427 cites W2026125300 @default.
• W2019054427 cites W2040572245 @default.
• W2019054427 cites W2048325091 @default.
• W2019054427 cites W2051729665 @default.
• W2019054427 cites W2052048055 @default.
• W2019054427 cites W2053620210 @default.
• W2019054427 cites W2054768922 @default.
• W2019054427 cites W2055464913 @default.
• W2019054427 cites W2071688202 @default.
• W2019054427 cites W2075181467 @default.
• W2019054427 cites W2082156530 @default.
• W2019054427 cites W2082775739 @default.
• W2019054427 cites W2085969552 @default.
• W2019054427 cites W2092312916 @default.
• W2019054427 cites W2095308764 @default.
• W2019054427 cites W2100117872 @default.
• W2019054427 cites W2104199760 @default.
• W2019054427 cites W2116195930 @default.
• W2019054427 cites W2132788558 @default.
• W2019054427 cites W2149120449 @default.
• W2019054427 cites W2158787913 @default.
• W2019054427 cites W2168370663 @default.
• W2019054427 cites W2168931543 @default.
• W2019054427 cites W2172383460 @default.
• W2019054427 cites W2196099160 @default.
• W2019054427 doi "https://doi.org/10.1073/pnas.92.17.8059" @default.
• W2019054427 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/41286" @default.
• W2019054427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7544014" @default.
• W2019054427 hasPublicationYear "1995" @default.
• W2019054427 type Work @default.
• W2019054427 sameAs 2019054427 @default.
• W2019054427 citedByCount "90" @default.
• W2019054427 countsByYear W20190544272013 @default.
• W2019054427 countsByYear W20190544272014 @default.
• W2019054427 countsByYear W20190544272015 @default.
• W2019054427 countsByYear W20190544272016 @default.
• W2019054427 countsByYear W20190544272018 @default.
• W2019054427 countsByYear W20190544272020 @default.
• W2019054427 countsByYear W20190544272022 @default.
• W2019054427 countsByYear W20190544272023 @default.
• W2019054427 crossrefType "journal-article" @default.
• W2019054427 hasAuthorship W2019054427A5006657863 @default.
• W2019054427 hasAuthorship W2019054427A5026676118 @default.
• W2019054427 hasAuthorship W2019054427A5046239561 @default.
• W2019054427 hasAuthorship W2019054427A5073494284 @default.
• W2019054427 hasAuthorship W2019054427A5083514131 @default.
• W2019054427 hasBestOaLocation W20190544271 @default.
• W2019054427 hasConcept C147483822 @default.
• W2019054427 hasConcept C148125776 @default.
• W2019054427 hasConcept C154317977 @default.
• W2019054427 hasConcept C202751555 @default.
• W2019054427 hasConcept C203014093 @default.
• W2019054427 hasConcept C22222904 @default.
• W2019054427 hasConcept C2776090121 @default.
• W2019054427 hasConcept C2778297628 @default.
• W2019054427 hasConcept C2781101188 @default.
• W2019054427 hasConcept C39347974 @default.
• W2019054427 hasConcept C55493867 @default.
• W2019054427 hasConcept C86803240 @default.
• W2019054427 hasConcept C8840205 @default.
• W2019054427 hasConcept C8891405 @default.
• W2019054427 hasConcept C95444343 @default.
• W2019054427 hasConceptScore W2019054427C147483822 @default.
• W2019054427 hasConceptScore W2019054427C148125776 @default.
• W2019054427 hasConceptScore W2019054427C154317977 @default.
• W2019054427 hasConceptScore W2019054427C202751555 @default.
• W2019054427 hasConceptScore W2019054427C203014093 @default.
• W2019054427 hasConceptScore W2019054427C22222904 @default.

• next