Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019057144> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2019057144 abstract "Cardioplegia-cardiopulmonary bypass (C/CPB) is associated with coronary microcirculatory dysfunction. Regulation of the microcirculation includes myogenic tone. Mitogen-activated protein kinases (MAPK) have been implicated in coronary vasomotor function. We hypothesized that vasomotor dysfunction of the coronary microcirculation is mediated in part by alterations in extracellular signal regulated kinase 1/2 (ERK1/2) activity following C/CPB in humans.Atrial myocardium was harvested from patients (n=15) before and after blood cardioplegia and short-term reperfusion under conditions of CPB. Myogenic tone of coronary arterioles was measured by videomicroscopy. Microvessel tone was determined post-C/CPB and after PD98059, a MAPK/ERK kinase 1/2 (MEK1/2) inhibitor. MAPK phosphatase-1 (MKP-1) and activated ERK1/2 were measured by Western blot. MKP-1 gene expression was determined by Northern blot. In situ hybridization and immunohistochemistry were used to localize myocardial MKP-1 and activated ERK1/2, respectively. Myogenic tone was reduced in coronary arterioles post-C/CPB (-10.5+/-0.9%, P<0.01 versus control/pre-C/CPB, n=5). Myogenic tone was decreased in coronary microvessels after 30 micromol/L (n=5) and 50 micromol/L (n=5) PD98059 treatment (-11.0+/-0.8% and -14.6+/-2.0%, respectively, both P<0.01 versus control/pre-C/CPB). Myocardial levels of activated ERK1/2 were reduced post-C/CPB (0.6+/-0.1, post/pre-C/CPB ratio, P<0.05, n=5) while MKP-1 levels increased (4.2+/-0.6, post/pre-C/CPB ratio, P<0.05, n=5). Myocardial MKP-1 gene expression increased post-C/CPB (3.0+/-0.8, post/pre-C/CPB ratio, P<0.05, n=5). MKP-1 and activated ERK1/2 localized to coronary arterioles in myocardial sections.Coronary myogenic tone is dependent on ERK1/2 and decreased after C/CPB. C/CPB reduces levels of activated ERK1/2, potentially by increased levels of MKP-1. The ERK1/2 signal transduction pathway in part mediates coronary microvascular dysfunction after C/CPB in humans." @default.
- W2019057144 created "2016-06-24" @default.
- W2019057144 creator A5012657061 @default.
- W2019057144 creator A5027150277 @default.
- W2019057144 creator A5039773127 @default.
- W2019057144 creator A5065626931 @default.
- W2019057144 creator A5073285577 @default.
- W2019057144 creator A5087184908 @default.
- W2019057144 creator A5088006371 @default.
- W2019057144 date "2003-09-09" @default.
- W2019057144 modified "2023-10-18" @default.
- W2019057144 title "Mitogen-Activated Protein Kinase Inhibition and Cardioplegia-Cardiopulmonary Bypass Reduce Coronary Myogenic Tone" @default.
- W2019057144 cites W1981456206 @default.
- W2019057144 cites W1990177246 @default.
- W2019057144 cites W2021708480 @default.
- W2019057144 cites W2028776847 @default.
- W2019057144 cites W2030741170 @default.
- W2019057144 cites W2037942010 @default.
- W2019057144 cites W2041879494 @default.
- W2019057144 cites W2090403899 @default.
- W2019057144 cites W2090685183 @default.
- W2019057144 cites W2121737503 @default.
- W2019057144 cites W2176084734 @default.
- W2019057144 cites W2259495851 @default.
- W2019057144 cites W2266199009 @default.
- W2019057144 cites W2296856157 @default.
- W2019057144 cites W2410925128 @default.
- W2019057144 doi "https://doi.org/10.1161/01.cir.0000087652.93751.0e" @default.
- W2019057144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12970258" @default.
- W2019057144 hasPublicationYear "2003" @default.
- W2019057144 type Work @default.
- W2019057144 sameAs 2019057144 @default.
- W2019057144 citedByCount "21" @default.
- W2019057144 countsByYear W20190571442013 @default.
- W2019057144 countsByYear W20190571442015 @default.
- W2019057144 countsByYear W20190571442016 @default.
- W2019057144 countsByYear W20190571442018 @default.
- W2019057144 countsByYear W20190571442023 @default.
- W2019057144 crossrefType "journal-article" @default.
- W2019057144 hasAuthorship W2019057144A5012657061 @default.
- W2019057144 hasAuthorship W2019057144A5027150277 @default.
- W2019057144 hasAuthorship W2019057144A5039773127 @default.
- W2019057144 hasAuthorship W2019057144A5065626931 @default.
- W2019057144 hasAuthorship W2019057144A5073285577 @default.
- W2019057144 hasAuthorship W2019057144A5087184908 @default.
- W2019057144 hasAuthorship W2019057144A5088006371 @default.
- W2019057144 hasBestOaLocation W20190571441 @default.
- W2019057144 hasConcept C126322002 @default.
- W2019057144 hasConcept C12722491 @default.
- W2019057144 hasConcept C164705383 @default.
- W2019057144 hasConcept C184235292 @default.
- W2019057144 hasConcept C2776214587 @default.
- W2019057144 hasConcept C2778881276 @default.
- W2019057144 hasConcept C2779676291 @default.
- W2019057144 hasConcept C541997718 @default.
- W2019057144 hasConcept C55493867 @default.
- W2019057144 hasConcept C57074206 @default.
- W2019057144 hasConcept C71924100 @default.
- W2019057144 hasConcept C86803240 @default.
- W2019057144 hasConceptScore W2019057144C126322002 @default.
- W2019057144 hasConceptScore W2019057144C12722491 @default.
- W2019057144 hasConceptScore W2019057144C164705383 @default.
- W2019057144 hasConceptScore W2019057144C184235292 @default.
- W2019057144 hasConceptScore W2019057144C2776214587 @default.
- W2019057144 hasConceptScore W2019057144C2778881276 @default.
- W2019057144 hasConceptScore W2019057144C2779676291 @default.
- W2019057144 hasConceptScore W2019057144C541997718 @default.
- W2019057144 hasConceptScore W2019057144C55493867 @default.
- W2019057144 hasConceptScore W2019057144C57074206 @default.
- W2019057144 hasConceptScore W2019057144C71924100 @default.
- W2019057144 hasConceptScore W2019057144C86803240 @default.
- W2019057144 hasIssue "10_suppl_1" @default.
- W2019057144 hasLocation W20190571441 @default.
- W2019057144 hasLocation W20190571442 @default.
- W2019057144 hasLocation W20190571443 @default.
- W2019057144 hasOpenAccess W2019057144 @default.
- W2019057144 hasPrimaryLocation W20190571441 @default.
- W2019057144 hasRelatedWork W1535503324 @default.
- W2019057144 hasRelatedWork W1981456206 @default.
- W2019057144 hasRelatedWork W1984468550 @default.
- W2019057144 hasRelatedWork W2010440482 @default.
- W2019057144 hasRelatedWork W2040174386 @default.
- W2019057144 hasRelatedWork W2116689599 @default.
- W2019057144 hasRelatedWork W2116899872 @default.
- W2019057144 hasRelatedWork W2187092729 @default.
- W2019057144 hasRelatedWork W2354359053 @default.
- W2019057144 hasRelatedWork W2793377893 @default.
- W2019057144 hasVolume "108" @default.
- W2019057144 isParatext "false" @default.
- W2019057144 isRetracted "false" @default.
- W2019057144 magId "2019057144" @default.
- W2019057144 workType "article" @default.