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- W2019063257 abstract "When root tips of Vicia faba were treated with 5-azacytidine (5-ACR) or 5-azadeoxycytidine (5-ACD) local uncoiling (segment extension) of specific chromosome segments and chromatid aberrations was produced. The peak of cells with segment extension was observed 2–8 h after treatment (non-delayed effect); cells with chromatid aberrations appeared after recovery times of more than 20 h (delayed effect). Colchicine labelling of cells after 5-ACR treatment showed that chromatid aberrations were present in 4n cells, i.e., they became induced during the interphase preceding the second mitosis. 5-ACR post-treatment after X-raying increased the frequency of X-ray-induced chromatid aberrations, and pretreatment was without influence on the aberration yield induced by X-rays alone. The preliminary conclusion drawn from the experimental results is that segment extension is due to the inhibition of RNA and, concomitantly, protein synthesis or the failure of complex formation between DNA and specific proteins. The incorporation of the analogues into DNA is presumed to be responsible for the induction of chromatid aberrations." @default.
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- W2019063257 title "On the induction of segment extension and chromatid structural changes in Vicia faba chromosomes after treatment with 5-azacytidine and 5-azadeoxycytidine" @default.
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- W2019063257 doi "https://doi.org/10.1016/0027-5107(70)90105-3" @default.
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