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- W2019063829 abstract "Platelet sensitivity to adenosine diphosphate and prostacyclin in diabetes has been assessed using collision theory and the concept of ‘sticking probability’ (the probability of particle union). Twenty Type 1 (insulin-dependent) diabetic men (10 with no or minimal retinopathy and a matched group of 10 with proliferative retinopathy) and 10 age-matched non-diabetic men were studied. Platelets from the 20 diabetic patients required, on average, 37% less adenosine diphosphate to achieve a sticking probability of 0.5 (ED50) compared with platelets from the non-diabetic subjects (medians 1.50 and 0.95 μmol/l, respectively; p<0.01). The platelet prostacyclin response was assessed by the dissociation constant (Ki) for inhibition of adenosine diphosphate-induced aggregation. Platelets from the diabetic patients had similar prostacyclin sensitivity to those from the non-diabetic subjects (medians 0.42 and 0.42 respectively). Diabetic patients with and without retinopathy had similar platelet sensitivity to both adenosine diphosphate and prostacyclin." @default.
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- W2019063829 date "1985-05-01" @default.
- W2019063829 modified "2023-09-26" @default.
- W2019063829 title "Platelet sensitivity in vitro to adenosine-5?-diphosphate and prostacyclin and diabetic retinopathy" @default.
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- W2019063829 doi "https://doi.org/10.1007/bf00271684" @default.
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