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• W2019065401 abstract "Olfactory-mediated chemotaxis in nematodes provides a relatively simple system to study biological mechanisms of information processing. Analysis of the kinetics of chemotaxis in response to 100% benzaldehyde revealed an initial attractive response that is followed by a strong aversion to the odorant. We show that this behavior is mediated by two genetically separable attraction- and aversion-mediating response pathways. The attraction initially dominates behavior but with prolonged exposure habituation leads to a behavioral change, such that the odorant becomes repulsive. This olfactory habituation is susceptible to dishabituation, thereby re-establishing the attractive response to the odorant. Re-examination of the putative olfactory adaptation mutant adp-1(ky20) revealed that the phenotype observed in this line is due to a supersensitivity to a dishabituating stimulus, rather than a defect in the adaptation to odorants per se. A modified benzaldehyde chemotaxis assay was developed and used for the isolation of a mutant with a specific defect in habituation kinetics, expressed as a persistence of the attractive response." @default.
• W2019065401 created "2016-06-24" @default.
• W2019065401 creator A5004302932 @default.
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• W2019065401 date "2001-05-01" @default.
• W2019065401 modified "2023-09-27" @default.
• W2019065401 title "Regulation of Distinct Attractive and Aversive Mechanisms Mediating Benzaldehyde Chemotaxis in<i>Caenorhabditis elegans</i>" @default.
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• W2019065401 doi "https://doi.org/10.1101/lm.36501" @default.
• W2019065401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/311371" @default.
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