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• W2019067595 abstract "<h2>Abstract</h2> We studied the extent of Ca²⁺ influx, myoplasmic free Ca²⁺ concentration changes, and phosphorylation of the regulatory 20-Kda myosin light chain (LC₂₀) associated with the potentiation of stretch-induced myogenic tone in the rabbit facial vein. The protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), was used to augment Ca²⁺-dependent stretch-induced myogenic tone. Veins stretched to an optimal resting tension in physiological salt solution (PSS) containing 0.4 mM of Ca²⁺ developed stretch-induced myogenic tone. Tissues incubated in Ca²⁺-free PSS, either with or without PMA (0.1 μM) did not develop myogenic tone. Readmission of Ca²⁺ (0.4 mM) caused three-fold increase in the contraction in PMA-treated segments (710 ± 60 mg, <i>n</i> = 29 <i>v</i> control: 188 ± 10 mg, <i>n</i> = 24). This increased contraction was not associated with additional increases in either Ca²⁺ influx (73.5 ± 6.9 pmol/mg of tissue/min, <i>n</i> = 29 <i>v</i> control: 61.1 ± 5.7 pmol/mg of tissue/min, <i>n</i> = 24), myoplasmic free Ca²⁺ concentration of LC₂₀, (0.44 ± 0.02 mol PO₄/mg LC₂₀, <i>n</i> = 9 <i>v</i> control: 0.43 ± 0.03 mol PO₄/mol LC₂₀, <i>n</i> = 7). Our results suggest that PKC activation amplifies stretch-induced myogenic tone in the rabbit facial vein through target proteins that are not associated with regulation of Ca²⁺ influx, myoplasmic free Ca²⁺ concentration, or LC₂₀ phosphorylation. We conclude that the PKC-mediated potentiation of stretch-induced myogenic tone is due to an increased sensitivity of the contractile apparatus to Ca²⁺." @default.
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• W2019067595 date "1994-03-01" @default.
• W2019067595 modified "2023-09-27" @default.
• W2019067595 title "Phorbol Ester-induced Potentiation of Myogenic Tone is not Associated with Increases in Ca2+ Influx, Myoplasmic Free Ca2+ Concentration, or 20-kDa Myosin Light Chain Phosphorylation" @default.
• W2019067595 doi "https://doi.org/10.1006/jmcc.1994.1038" @default.
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