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• W2019069084 abstract "This paper reports the study on applicability of Fourier transform infrared (FTIR), near-infrared (NIR) and Raman spectroscopy, differential scanning calorimetry (DSC) and X-ray diffraction (XRD) for the estimation of the chemical stability and photostability of histamine H2-receptor antagonist substances. Ranitidine hydrochloride (RAN), famotidine (FAM) and cimetidine (CIM) were tested and differences in sensitivity were measured via soft independence modeling of class analogies (Simca) model. The low values of variations for FAM and CIM and high variations obtained for RAN using FTIR and NIR techniques indicated that these methods were suitable and applicable to classify the degradation of RAN. Examined methods are recommendable in the first technological stage of drug production, and the preclinical and clinical development of pharmaceuticals or their quality control." @default.
• W2019069084 created "2016-06-24" @default.
• W2019069084 creator A5043266517 @default.
• W2019069084 creator A5063055761 @default.
• W2019069084 date "2015-03-01" @default.
• W2019069084 modified "2023-09-27" @default.
• W2019069084 title "Application of vibrational spectroscopy, thermal analyses and X-ray diffraction in the rapid evaluation of the stability in solid-state of ranitidine, famotidine and cimetidine" @default.
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• W2019069084 doi "https://doi.org/10.1016/j.jpba.2015.01.012" @default.
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