Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019070556> ?p ?o ?g. }
- W2019070556 abstract "Alcohol withdrawal syndrome (AWS) is characterized by a set of physiological modifications triggered by abrupt withdrawal and/or decreasing consumption of ethanol (EtOH), which may manifest 16-48 h after ceasing consumption. The relationship between the effects of AWS and central and peripheral sympathetic neurotransmission is unknown. This study investigates the possible mechanisms on the sympathetic system during periods of AWS.Male Wistar rats were treated with EtOH (6-10 g/kg/day/v.o. 5 days). Subsequently, 1h, 24h, 48 h and 120 h after administration of the last dose of EtOH, the animals were sacrificed, and their vas deferens (VD) were removed to perform the following evaluations: (a) concentration-effect curves of sympathetic agonist; (b) activity of α2-adrenoreceptor; (c) function of voltage-dependent calcium channels (Cav); and (d) release of endogenous catecholamines measured in real time coupled to HPLC.The results showed that the maximum effects of contraction were increased by agonists tested in at 24h and 48 h EtOH withdrawal. The inhibitory affinity (pIC50) of guanfacine was decreased 24h EtOH withdrawal. The function of Cav was also decreased as pIC50 values dropped 24h and 48 h EtOH withdrawal. The release of catecholamines increased 48 h after EtOH withdrawal. It is suggested that AWS triggers hyperactivity in peripheral sympathetic neurotransmission.The mechanisms underlying hyperactivity are possibly explained by a failure of autoregulation from catecholamines released by α2-adrenoreceptors and/or an increase of Cav function, which may be potential targets to attenuate the symptoms of AWS at the peripheral level." @default.
- W2019070556 created "2016-06-24" @default.
- W2019070556 creator A5001723284 @default.
- W2019070556 creator A5002946751 @default.
- W2019070556 creator A5029269835 @default.
- W2019070556 creator A5053148229 @default.
- W2019070556 creator A5077662849 @default.
- W2019070556 date "2014-07-01" @default.
- W2019070556 modified "2023-10-01" @default.
- W2019070556 title "Functional effects of alcohol withdrawal syndrome on peripheral sympathetic neurotransmission in vas deferens of adult rats" @default.
- W2019070556 cites W1526918182 @default.
- W2019070556 cites W1560980017 @default.
- W2019070556 cites W1785031413 @default.
- W2019070556 cites W181776045 @default.
- W2019070556 cites W1876592273 @default.
- W2019070556 cites W1950972906 @default.
- W2019070556 cites W1965051624 @default.
- W2019070556 cites W1972551153 @default.
- W2019070556 cites W1978013837 @default.
- W2019070556 cites W1980185263 @default.
- W2019070556 cites W1985173185 @default.
- W2019070556 cites W1988661220 @default.
- W2019070556 cites W1992680021 @default.
- W2019070556 cites W1996422177 @default.
- W2019070556 cites W1998864147 @default.
- W2019070556 cites W1999608537 @default.
- W2019070556 cites W2000626957 @default.
- W2019070556 cites W2000923181 @default.
- W2019070556 cites W2005371311 @default.
- W2019070556 cites W2014624016 @default.
- W2019070556 cites W2021997881 @default.
- W2019070556 cites W2022059703 @default.
- W2019070556 cites W2027859583 @default.
- W2019070556 cites W2029370605 @default.
- W2019070556 cites W2031749541 @default.
- W2019070556 cites W2033548135 @default.
- W2019070556 cites W2035802806 @default.
- W2019070556 cites W2037043076 @default.
- W2019070556 cites W2039932609 @default.
- W2019070556 cites W2041561931 @default.
- W2019070556 cites W2042119083 @default.
- W2019070556 cites W2055664813 @default.
- W2019070556 cites W2061696440 @default.
- W2019070556 cites W2067278607 @default.
- W2019070556 cites W2071319050 @default.
- W2019070556 cites W2071988467 @default.
- W2019070556 cites W2076054717 @default.
- W2019070556 cites W2093543101 @default.
- W2019070556 cites W2095164603 @default.
- W2019070556 cites W2123705832 @default.
- W2019070556 cites W2160013579 @default.
- W2019070556 cites W224473223 @default.
- W2019070556 cites W2316097148 @default.
- W2019070556 cites W2414843389 @default.
- W2019070556 cites W2419485515 @default.
- W2019070556 cites W2955504961 @default.
- W2019070556 cites W53392061 @default.
- W2019070556 cites W2412271225 @default.
- W2019070556 doi "https://doi.org/10.1016/j.lfs.2014.05.002" @default.
- W2019070556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24831557" @default.
- W2019070556 hasPublicationYear "2014" @default.
- W2019070556 type Work @default.
- W2019070556 sameAs 2019070556 @default.
- W2019070556 citedByCount "3" @default.
- W2019070556 countsByYear W20190705562015 @default.
- W2019070556 countsByYear W20190705562017 @default.
- W2019070556 crossrefType "journal-article" @default.
- W2019070556 hasAuthorship W2019070556A5001723284 @default.
- W2019070556 hasAuthorship W2019070556A5002946751 @default.
- W2019070556 hasAuthorship W2019070556A5029269835 @default.
- W2019070556 hasAuthorship W2019070556A5053148229 @default.
- W2019070556 hasAuthorship W2019070556A5077662849 @default.
- W2019070556 hasConcept C126322002 @default.
- W2019070556 hasConcept C134018914 @default.
- W2019070556 hasConcept C170493617 @default.
- W2019070556 hasConcept C178790620 @default.
- W2019070556 hasConcept C185592680 @default.
- W2019070556 hasConcept C200170125 @default.
- W2019070556 hasConcept C2778210472 @default.
- W2019070556 hasConcept C2778938600 @default.
- W2019070556 hasConcept C2780161600 @default.
- W2019070556 hasConcept C71924100 @default.
- W2019070556 hasConceptScore W2019070556C126322002 @default.
- W2019070556 hasConceptScore W2019070556C134018914 @default.
- W2019070556 hasConceptScore W2019070556C170493617 @default.
- W2019070556 hasConceptScore W2019070556C178790620 @default.
- W2019070556 hasConceptScore W2019070556C185592680 @default.
- W2019070556 hasConceptScore W2019070556C200170125 @default.
- W2019070556 hasConceptScore W2019070556C2778210472 @default.
- W2019070556 hasConceptScore W2019070556C2778938600 @default.
- W2019070556 hasConceptScore W2019070556C2780161600 @default.
- W2019070556 hasConceptScore W2019070556C71924100 @default.
- W2019070556 hasLocation W20190705561 @default.
- W2019070556 hasLocation W20190705562 @default.
- W2019070556 hasOpenAccess W2019070556 @default.
- W2019070556 hasPrimaryLocation W20190705561 @default.
- W2019070556 hasRelatedWork W1970287328 @default.
- W2019070556 hasRelatedWork W2019080786 @default.
- W2019070556 hasRelatedWork W2027913950 @default.
- W2019070556 hasRelatedWork W2028293475 @default.