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- W2019071728 abstract "use a mouse model to study theeffects of IMD in relation to the importantclinical problem of myocardial ischemia–reperfusion injury. The role of IMD in thispathological condition remains poorly under-stood, and little is known with regard tochanges in the expression of IMD and thereceptor components. In the current investi-gation, the authors use a mouse model invol-ving ligation of the left descending artery.They report that there are changes inducedin pulse pressure and heart rate followinginduction of infarction and reperfusion.With respect to furthering our understandingof ischemia–reperfusion, it is important tonote that there were also changes in factorsassociated with IMD. Observations includedraised levels of IMD in plasma and of expres-sion in the infarcted area. In addition, therewas modulation of receptor activity-modify-ing protein (RAMP)2 and RAMP3 expres-sion. The peptide was administered to con-sider the effects of IMD, and these includedreduction in the size of the necrotic area.Furthermore, levels of IMD in blood werepositively associated with diastolic bloodpressure and negatively associated withpulse pressure. These results are consistentwith a cardioprotective function.The authors have supplied new informa-tion on the response and potential role ofIMD in myocardial ischemia–reperfusioninjury. This is important in light of theknowledge that there are a number of endo-genous bioactive factors involved in cardio-vascular control. These include the peptidesendothelin-1, CNP, angiotensin-II, urocortinand adrenomedullin (ADM), among others.To understand (and therefore control) thesystem, it is necessary to delineate the distincteffects of the different peptides. The activitiesand responses of the peptides will potentiallycomplement each other in physiological func-tioning by being activated in different cir-cumstances.The relationship between IMD and ADMis of particular interest because of their struc-tural similarity and the possibility that theycomprise a distinct family within the calcito-nin gene-related peptide superfamily." @default.
- W2019071728 created "2016-06-24" @default.
- W2019071728 creator A5050390201 @default.
- W2019071728 date "2009-08-14" @default.
- W2019071728 modified "2023-10-09" @default.
- W2019071728 title "Toward revealing the roles for intermedin in the community of vasoactive peptides" @default.
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- W2019071728 doi "https://doi.org/10.1038/hr.2009.127" @default.
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