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• W2019072783 abstract "The C57 BL/6J dy2J/dy2J dystrophic mouse expresses an abnormal truncated form of the alpha2 subunit of the protein laminin-2 (or merosin), which is unable to form a stable link between the extracellular matrix and the dystrophin-associated proteins, resulting in muscular dystrophy. Morphological abnormalities of the peripheral nervous system and neuromuscular junction have also been reported. The electrophysiological properties of the neuromuscular junctions of diaphragm, extensor digitorum longus (EDL), and soleus from C57 BL/6J dy2J/dy2J mice and controls are described. No evidence for the presence of denervated fibres were found. Mean MEPP amplitudes were significantly increased in EDL and soleus but reduced in the diaphragm from affected mice. Mean MEPP frequencies were raised in all the dy2J/dy2J muscles studied. dy2J/dy2J muscles were paralysed by low concentrations of mu-conotoxin suggesting that embryonic (tetrodotoxin and mu-conotoxin resistant) sodium channels are not widespread on dy2J/dy2J muscle as has previously been reported. EPP latencies were significantly prolonged in the diaphragm and EDL but not soleus from dy2J/dy2J mice. Quantal contents were higher in all dy2J/dy2J muscles. In the dy2J/dy2J diaphragm failures in neurotransmission occurred and a faster rate of rundown of EPPs were apparent. Some changes appear from a direct effect of dystrophy, whilst increased MEPP frequency and quantal content, and failures in neurotransmission indicate neuronal abnormalities." @default.
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• W2019072783 date "1998-03-01" @default.
• W2019072783 modified "2023-09-27" @default.
• W2019072783 title "Electrophysiology of the neuromuscular junction of the laminin-2 (merosin) deficient C57 BL/6J dy2J/dy2J dystrophic mouse" @default.
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• W2019072783 doi "https://doi.org/10.1016/s0006-8993(98)00010-9" @default.
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