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- W2019075363 abstract "The effects of intrathecal administration of substance P and Symbol (NMDA) were studied in the formalin test in mice. Both substances were administered 5 min before injection of formalin into the hind paw. Co-administration of substance P and NMDA intensified the response in both the 1st (0–10 min) and the 2nd phase (20–30 min) of the formalin test, and increased the duration of the response. The increase in the response to formalin depended on the formalin concentration and was significant with 1% and 5% concentrations of formalin but not with a 0.05% concentration. No increase in the response was observed when NMDA or substance P was given alone. These findings indicate that concurrent activation of spinal NMDA and substance P receptors induces an enhancement of spinal transmission of nociception, and that this enhancement is dependent on the intensity or the quality of the peripheral stimulus." @default.
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- W2019075363 title "Intrathecal co-administration of substance P and NMDA augments nociceptive responses in the formalin test" @default.
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- W2019075363 doi "https://doi.org/10.1016/0304-3959(92)90260-i" @default.
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