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- W2019082654 abstract "Cryostat sections of trout brains were incubated with tritiated opioid ligands (5 nM [3H]etorphine or 4 nMd-[3H]Ala2, Met5 enkephalinamide) with the initial aim of locating opioid binding sites associated with the hypothalamo-pituitary axis. Naloxone-displaceable binding was observed in all regions of the brain, with a density ranking order of cerebellum > telencephalon > optic tectum > hypothalamus > brain stem > pituitary gland. Within the hypothalamus and pituitary gland binding was unexpectedly low, apart from a slightly enhanced binding anteriorly in the preoptic region and posteriorly associated with presumptive sensory fibres. A similar distribution of opioid binding sites was seen in the eel and lamprey brain. The high level of opioid binding in the cerebellum permitted a tentative identification of opioid subtypes using [3H]etorphine binding to membrane preparations from trout cerebellum. Scatchard analysis indicated the presence of a single class of high-affinity binding sites with a density of 0.38 pmol/mg protein and affinity constant (KD) of 2.6 nM. Displacement by unlabelled ligands suggested the existance of μ and/or κ receptors." @default.
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- W2019082654 date "1988-04-01" @default.
- W2019082654 modified "2023-10-18" @default.
- W2019082654 title "Opioid binding sites in the fish brain: An autoradiographic study" @default.
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- W2019082654 doi "https://doi.org/10.1016/0016-6480(88)90093-7" @default.
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