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• W2019083828 abstract "Beta-sitosterol 3-beta-D-glucoside (Sit-G), an absorption enhancer, was incorporated into ultra-deformable vesicles containing bleomycin to attenuate drug toxicity in human keratinocytes. The presence of Sit-G increased drug entrapment and improved in vitro stability of ultra-deformable vesicles. Confocal laser scanning microscopy revealed the extent to which Sit-G facilitated the penetration of ultra-deformable vesicles containing fluorescent probes into rat skin upon non-occlusive topical application. Furthermore, treatment with preparations incorporating Sit-G resulted in elevated epidermal and dermal concentrations of bleomycin. Ultra-deformable formulation contained Sit-G maintained flexibility for penetration through the skin, increased entrapment efficiency of bleomycin and stability in vitro, and significantly increased distribution of bleomycin in epidermis and dermis compared with those without Sit-G." @default.
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• W2019083828 date "2006-06-01" @default.
• W2019083828 modified "2023-10-18" @default.
• W2019083828 title "Novel ultra-deformable vesicles entrapped with bleomycin and enhanced to penetrate rat skin" @default.
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• W2019083828 doi "https://doi.org/10.1016/j.jconrel.2006.04.016" @default.
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