FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019085305> ?p ?o ?g. }

• W2019085305 endingPage "235" @default.
• W2019085305 startingPage "228" @default.
• W2019085305 abstract "The anorexia associated with acute and chronic inflammatory or infectious conditions is poorly understood. Our objectives were to explore the anorexigenic effects of interleukin-1 (IL-1) in the rat. Recombinant human (rh) IL-1 beta, murine (rm) IL-1 alpha and to a lesser extent rhIL-1 alpha significantly reduced food intake at greater than or equal to 4.0 micrograms/kg i.p. but not at lower doses, in young (200-250 g) meal-fed rats on chow diets. The anorexic effect appears to be mediated by prostaglandins since pretreatment with ibuprofen completely blocked it, and a fish oil based diet abolished it, in comparison to corn oil or chow diets. Fish oil feeding also decreased basal and IL-1 stimulated prostaglandin E2 production by tissues in vitro (liver, brain, peritoneal macrophages) and in the whole body. Constant intravenous infusions of lower doses of IL-1 also diminished food intake, though intravenous boluses did not (reflecting rapid renal clearance). Chronic daily administration of IL-1 caused persistent inhibition of food intake for 7-17 d in chow and corn oil fed rats, but had no effect in fish oil fed rats. There was an attenuation of the effect (tachyphylaxis) after 7 d in corn oil and chow fed rats, but slowed weight gain and lower final weights were observed after 17-32 d of daily IL-1. Old (18-20 mo Fisher 344) rats showed less sensitivity to IL-1 induced anorexia. In conclusion, IL-1 is anorexigenic in the rat, but this is influenced by the structural form of IL-1, the route and chronicity of administration, the source of dietary fat, and the age of the animal. The ability of prior fat intake to influence the anorexic response to IL-1 represents a novel nutrient-nutrient interaction with potential therapeutic implications." @default.
• W2019085305 created "2016-06-24" @default.
• W2019085305 creator A5001814538 @default.
• W2019085305 creator A5005742957 @default.
• W2019085305 creator A5026672801 @default.
• W2019085305 creator A5052173701 @default.
• W2019085305 creator A5073926662 @default.
• W2019085305 date "1989-07-01" @default.
• W2019085305 modified "2023-10-17" @default.
• W2019085305 title "Interleukin-1-induced anorexia in the rat. Influence of prostaglandins." @default.
• W2019085305 cites W124490651 @default.
• W2019085305 cites W1493935825 @default.
• W2019085305 cites W1500431308 @default.
• W2019085305 cites W1504880517 @default.
• W2019085305 cites W1521683858 @default.
• W2019085305 cites W1647673633 @default.
• W2019085305 cites W1837837142 @default.
• W2019085305 cites W1860755221 @default.
• W2019085305 cites W1907434951 @default.
• W2019085305 cites W1908154520 @default.
• W2019085305 cites W1965860042 @default.
• W2019085305 cites W1988407725 @default.
• W2019085305 cites W1999578729 @default.
• W2019085305 cites W2003880412 @default.
• W2019085305 cites W2004515700 @default.
• W2019085305 cites W2007486574 @default.
• W2019085305 cites W2011291552 @default.
• W2019085305 cites W2012258375 @default.
• W2019085305 cites W2023265227 @default.
• W2019085305 cites W2028355250 @default.
• W2019085305 cites W2030567410 @default.
• W2019085305 cites W2031118621 @default.
• W2019085305 cites W2045972005 @default.
• W2019085305 cites W2048540725 @default.
• W2019085305 cites W2049781503 @default.
• W2019085305 cites W2055054372 @default.
• W2019085305 cites W2070095270 @default.
• W2019085305 cites W2076433657 @default.
• W2019085305 cites W2079094885 @default.
• W2019085305 cites W2122462682 @default.
• W2019085305 cites W2125001573 @default.
• W2019085305 cites W2129644831 @default.
• W2019085305 cites W2133605422 @default.
• W2019085305 cites W2135745523 @default.
• W2019085305 cites W2137957747 @default.
• W2019085305 cites W2139976602 @default.
• W2019085305 cites W2148978503 @default.
• W2019085305 cites W2158878726 @default.
• W2019085305 cites W2163263711 @default.
• W2019085305 cites W2164322090 @default.
• W2019085305 cites W2166542918 @default.
• W2019085305 cites W2171798479 @default.
• W2019085305 cites W2321334948 @default.
• W2019085305 cites W2327515496 @default.
• W2019085305 cites W2395383501 @default.
• W2019085305 cites W2410792081 @default.
• W2019085305 cites W4247254714 @default.
• W2019085305 cites W840308884 @default.
• W2019085305 cites W2413464017 @default.
• W2019085305 doi "https://doi.org/10.1172/jci114145" @default.
• W2019085305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/303974" @default.
• W2019085305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2786888" @default.
• W2019085305 hasPublicationYear "1989" @default.
• W2019085305 type Work @default.
• W2019085305 sameAs 2019085305 @default.
• W2019085305 citedByCount "318" @default.
• W2019085305 countsByYear W20190853052012 @default.
• W2019085305 countsByYear W20190853052013 @default.
• W2019085305 countsByYear W20190853052014 @default.
• W2019085305 countsByYear W20190853052015 @default.
• W2019085305 countsByYear W20190853052016 @default.
• W2019085305 countsByYear W20190853052017 @default.
• W2019085305 countsByYear W20190853052018 @default.
• W2019085305 countsByYear W20190853052019 @default.
• W2019085305 countsByYear W20190853052021 @default.
• W2019085305 crossrefType "journal-article" @default.
• W2019085305 hasAuthorship W2019085305A5001814538 @default.
• W2019085305 hasAuthorship W2019085305A5005742957 @default.
• W2019085305 hasAuthorship W2019085305A5026672801 @default.
• W2019085305 hasAuthorship W2019085305A5052173701 @default.
• W2019085305 hasAuthorship W2019085305A5073926662 @default.
• W2019085305 hasBestOaLocation W20190853051 @default.
• W2019085305 hasConcept C126322002 @default.
• W2019085305 hasConcept C134018914 @default.
• W2019085305 hasConcept C170493617 @default.
• W2019085305 hasConcept C185592680 @default.
• W2019085305 hasConcept C2778206080 @default.
• W2019085305 hasConcept C2778654693 @default.
• W2019085305 hasConcept C2779946292 @default.
• W2019085305 hasConcept C2780664492 @default.
• W2019085305 hasConcept C2909208804 @default.
• W2019085305 hasConcept C42533223 @default.
• W2019085305 hasConcept C505870484 @default.
• W2019085305 hasConcept C71924100 @default.
• W2019085305 hasConcept C86803240 @default.
• W2019085305 hasConceptScore W2019085305C126322002 @default.
• W2019085305 hasConceptScore W2019085305C134018914 @default.
• W2019085305 hasConceptScore W2019085305C170493617 @default.

• next