Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019091330> ?p ?o ?g. }
- W2019091330 endingPage "1848" @default.
- W2019091330 startingPage "1839" @default.
- W2019091330 abstract "Gene therapy presents a unique opportunity for the treatment of genetic diseases, but the lack of multifunctional delivery systems has hindered its clinical applications. Here, a new delivery vector, autofluorescent polyethyleneimine (PEI) nanogels, for highly efficient and traceable gene delivery is developed. Different from commercial high‐molecular‐weight PEI, the cationic nanogels are noncytotoxic and able to be fragmented due to their unique intracellular microenvironment‐responsive structures. The biodegradable nanogels can effectively load plasmid DNA (pDNA), and the self‐assembled polyplexes can be cleaved after cellular uptake to improve gene transfection efficiency. Most importantly, the nanogels and the nanogel/pDNA polyplexes are autofluorescent. The fluorescence is stable in blood plasma and responsive to the intracellular microenvironment. The breakup of the nanogels or polyplexes leads to the loss of fluorescence, and thus the gene delivery and carrier biodegradation processes can be monitored. The reported multifunctional system demonstrates excellent biocompatibility, high transfection efficiency, responsive biodegradability, controlled gene release, label‐free and simultaneous fluorescence tracking, which will provide a new platform for future scientific investigation and practical implications in gene therapy." @default.
- W2019091330 created "2016-06-24" @default.
- W2019091330 creator A5026398494 @default.
- W2019091330 creator A5026786676 @default.
- W2019091330 creator A5032628543 @default.
- W2019091330 creator A5048667355 @default.
- W2019091330 creator A5058435392 @default.
- W2019091330 date "2014-06-26" @default.
- W2019091330 modified "2023-10-16" @default.
- W2019091330 title "Intracellular Microenvironment-Responsive Label-Free Autofluorescent Nanogels for Traceable Gene Delivery" @default.
- W2019091330 cites W1891967301 @default.
- W2019091330 cites W1964146045 @default.
- W2019091330 cites W1970396244 @default.
- W2019091330 cites W1973458116 @default.
- W2019091330 cites W1973685571 @default.
- W2019091330 cites W1975606985 @default.
- W2019091330 cites W1979146520 @default.
- W2019091330 cites W1981937567 @default.
- W2019091330 cites W1982194357 @default.
- W2019091330 cites W1982461928 @default.
- W2019091330 cites W1983361018 @default.
- W2019091330 cites W1991845461 @default.
- W2019091330 cites W1994233420 @default.
- W2019091330 cites W1994603439 @default.
- W2019091330 cites W1998697301 @default.
- W2019091330 cites W2003414091 @default.
- W2019091330 cites W2004028065 @default.
- W2019091330 cites W2005502779 @default.
- W2019091330 cites W2006026842 @default.
- W2019091330 cites W2008033906 @default.
- W2019091330 cites W2013841789 @default.
- W2019091330 cites W2014356856 @default.
- W2019091330 cites W2020246410 @default.
- W2019091330 cites W2022444637 @default.
- W2019091330 cites W2037595752 @default.
- W2019091330 cites W2040071171 @default.
- W2019091330 cites W2047033241 @default.
- W2019091330 cites W2049109647 @default.
- W2019091330 cites W2054790400 @default.
- W2019091330 cites W2059262359 @default.
- W2019091330 cites W2063193372 @default.
- W2019091330 cites W2065076242 @default.
- W2019091330 cites W2065873445 @default.
- W2019091330 cites W2070802503 @default.
- W2019091330 cites W2073381246 @default.
- W2019091330 cites W2081245603 @default.
- W2019091330 cites W2091684003 @default.
- W2019091330 cites W2092447252 @default.
- W2019091330 cites W2093776019 @default.
- W2019091330 cites W2100811292 @default.
- W2019091330 cites W2101101478 @default.
- W2019091330 cites W2103715885 @default.
- W2019091330 cites W2108969731 @default.
- W2019091330 cites W2110271242 @default.
- W2019091330 cites W2118271807 @default.
- W2019091330 cites W2121171143 @default.
- W2019091330 cites W2131009342 @default.
- W2019091330 cites W2132878122 @default.
- W2019091330 cites W2144140236 @default.
- W2019091330 cites W2154157809 @default.
- W2019091330 cites W2157207470 @default.
- W2019091330 cites W2160531882 @default.
- W2019091330 cites W2163371839 @default.
- W2019091330 cites W2326744837 @default.
- W2019091330 cites W4229814048 @default.
- W2019091330 cites W4232930875 @default.
- W2019091330 cites W4242428555 @default.
- W2019091330 cites W61869633 @default.
- W2019091330 doi "https://doi.org/10.1002/adhm.201400187" @default.
- W2019091330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24965262" @default.
- W2019091330 hasPublicationYear "2014" @default.
- W2019091330 type Work @default.
- W2019091330 sameAs 2019091330 @default.
- W2019091330 citedByCount "26" @default.
- W2019091330 countsByYear W20190913302015 @default.
- W2019091330 countsByYear W20190913302016 @default.
- W2019091330 countsByYear W20190913302017 @default.
- W2019091330 countsByYear W20190913302018 @default.
- W2019091330 countsByYear W20190913302019 @default.
- W2019091330 countsByYear W20190913302020 @default.
- W2019091330 countsByYear W20190913302021 @default.
- W2019091330 countsByYear W20190913302022 @default.
- W2019091330 crossrefType "journal-article" @default.
- W2019091330 hasAuthorship W2019091330A5026398494 @default.
- W2019091330 hasAuthorship W2019091330A5026786676 @default.
- W2019091330 hasAuthorship W2019091330A5032628543 @default.
- W2019091330 hasAuthorship W2019091330A5048667355 @default.
- W2019091330 hasAuthorship W2019091330A5058435392 @default.
- W2019091330 hasConcept C104317684 @default.
- W2019091330 hasConcept C111599444 @default.
- W2019091330 hasConcept C12554922 @default.
- W2019091330 hasConcept C134424308 @default.
- W2019091330 hasConcept C135983454 @default.
- W2019091330 hasConcept C171250308 @default.
- W2019091330 hasConcept C185592680 @default.
- W2019091330 hasConcept C191897082 @default.
- W2019091330 hasConcept C192562407 @default.
- W2019091330 hasConcept C2775925850 @default.