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• W2019092555 endingPage "537" @default.
• W2019092555 startingPage "537" @default.
• W2019092555 abstract "<h3>Context</h3> Polymorphisms in the promoter region of the serotonin transporter gene (<i>5-HTTLPR</i>) influence transcription and may play a role in the pathogenesis and course of depression. Recent research demonstrates that specific polymorphisms may be associated with differences in hippocampal volumes in subjects with depression. <h3>Objective</h3> To examine associations between<i>5-HTTLPR</i>genotype and hippocampal volumes in elderly control subjects and elderly subjects classified as having early or late onset of depression. <h3>Design</h3> Cohort study examining baseline characteristics. <h3>Participants</h3> Subjects were community dwelling and 60 years or older. Using a definition of early-onset depression as depression first occurring at 50 years or younger, we examined 72 subjects with early-onset depression, 63 subjects with late-onset depression, and 83 healthy control subjects. <h3>Main Outcome Measures</h3> All subjects underwent genotyping for the<i>5-HTTLPR</i>and underwent brain magnetic resonance imaging. Analyses of hippocampal volumes were controlled for total cerebral volume, age, and sex. <h3>Results</h3> The interaction between diagnosis and<i>5-HTTLPR</i>genotype was statistically significant for the right hippocampus (<i>P</i> = .04). Subjects with late-onset depression who were homozygous for the long (L) allele (L /L genotype) had significantly smaller right hippocampal volumes than did L /L subjects with early-onset depression (<i>P</i> = .046) or L /L control subjects (<i>P</i> = .01). Post hoc analyses showed that later age of depression onset was associated with smaller hippocampal volumes in subjects with the L /L genotype, but earlier age of onset was associated with smaller hippocampal volumes in subjects who were homozygous for the short (S) allele (S/S genotype). <h3>Conclusions</h3> Subjects with late-onset depression who were homozygous for the L allele exhibited smaller hippocampal volumes than other groups. Genotype also mediated the effect of age of onset on hippocampal volumes. Our findings differ from previous work; however, we examined an older and larger cohort of subjects than previous studies. Possible explanations for these findings include interactions between the serotonergic system and neurotrophic factors or cortisol response to stresses, each of which may affect hippocampal volumes." @default.
• W2019092555 created "2016-06-24" @default.
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• W2019092555 date "2005-05-01" @default.
• W2019092555 modified "2023-10-16" @default.
• W2019092555 title "Influence of Serotonin Transporter Promoter Region Polymorphisms on Hippocampal Volumes in Late-Life Depression" @default.
• W2019092555 cites W1550462067 @default.
• W2019092555 cites W167911861 @default.
• W2019092555 cites W1871684389 @default.
• W2019092555 cites W1894736765 @default.
• W2019092555 cites W1963525383 @default.
• W2019092555 cites W1965135336 @default.
• W2019092555 cites W1968483037 @default.
• W2019092555 cites W1970278197 @default.
• W2019092555 cites W1975261575 @default.
• W2019092555 cites W1981684805 @default.
• W2019092555 cites W1985615293 @default.
• W2019092555 cites W1988306858 @default.
• W2019092555 cites W1989060739 @default.
• W2019092555 cites W1993999110 @default.
• W2019092555 cites W1999066662 @default.
• W2019092555 cites W2002050752 @default.
• W2019092555 cites W2002101479 @default.
• W2019092555 cites W2005534453 @default.
• W2019092555 cites W2012864192 @default.
• W2019092555 cites W2013336473 @default.
• W2019092555 cites W2019316537 @default.
• W2019092555 cites W2028173302 @default.
• W2019092555 cites W2032398883 @default.
• W2019092555 cites W2034455408 @default.
• W2019092555 cites W2035244151 @default.
• W2019092555 cites W2042673885 @default.
• W2019092555 cites W2042879498 @default.
• W2019092555 cites W2045222664 @default.
• W2019092555 cites W2050768782 @default.
• W2019092555 cites W2051030609 @default.
• W2019092555 cites W2051118254 @default.
• W2019092555 cites W2053645387 @default.
• W2019092555 cites W2055595234 @default.
• W2019092555 cites W2061730652 @default.
• W2019092555 cites W2062113276 @default.
• W2019092555 cites W2066238082 @default.
• W2019092555 cites W2069026305 @default.
• W2019092555 cites W2072376264 @default.
• W2019092555 cites W2074243049 @default.
• W2019092555 cites W2076614161 @default.
• W2019092555 cites W2085438951 @default.
• W2019092555 cites W2085447556 @default.
• W2019092555 cites W2097408153 @default.
• W2019092555 cites W2098349177 @default.
• W2019092555 cites W2106095564 @default.
• W2019092555 cites W2110763068 @default.
• W2019092555 cites W2111424618 @default.
• W2019092555 cites W2116152046 @default.
• W2019092555 cites W2120032880 @default.
• W2019092555 cites W2121878996 @default.
• W2019092555 cites W2125901028 @default.
• W2019092555 cites W2131494510 @default.
• W2019092555 cites W2131652233 @default.
• W2019092555 cites W2131823335 @default.
• W2019092555 cites W2133258067 @default.
• W2019092555 cites W2133518193 @default.
• W2019092555 cites W2134748447 @default.
• W2019092555 cites W2136749432 @default.
• W2019092555 cites W2137114476 @default.
• W2019092555 cites W2151041365 @default.
• W2019092555 cites W2162196924 @default.
• W2019092555 cites W2171789142 @default.
• W2019092555 cites W2323877356 @default.
• W2019092555 cites W2335690246 @default.
• W2019092555 cites W2418689004 @default.
• W2019092555 cites W94283631 @default.
• W2019092555 doi "https://doi.org/10.1001/archpsyc.62.5.537" @default.
• W2019092555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15867107" @default.
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