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- W2019094219 abstract "SummaryPrevious work has demonstrated that radiation exposure modulates the expression of a series of genes, including those that encode cytoskeletal elements. The experiments reported here were designed to examine (1) the comparative effects of neutrons administered at high versus low dose-rates, (2) the comparative effects of neutrons on cycling versus resting cells and (3) the comparative effects of neutrons versus γ-rays on β- and γ-actin mRNA accumulation in Syrian hamster embryo (SHE) cells 1 and 3 h post-irradiation. JANUS fission-spectrum neutrons from Argonne National Laboratory's JANUS reactor administered at high (12 cGy/min) dose-rates had little effect on resting cells, but at very low dose-rates (0·1 cGy/min) had a repressive effect on γ-actin mRNA accumulation. Increased accumulation of β-actin mRNA was detected following the exposure of cells to neutrons administered at high dose-rates, but repression of β-actin mRNA was observed when neutrons were administered at low dose-rates. Cycling cells (unexposed and neutron irradiated) in all cases expressed higher levels of all actin-specific mRNAs than resting cells; β-actin mRNA (but not γ-actin mRNA) was induced to a greater extent in cycling cells than in resting cells during the first hour following neutron exposure. In resting cells, however, low dose-rate neutrons were more effective than low dose-rate γ-rays at repressing both γ- and β-actin mRNA accumulation. These results demonstrate the differential effects of radiation quality (neutrons versus γ-rays) and cell-cycle state on the modulation of actin isotype-specific gene expression." @default.
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- W2019094219 date "1991-01-01" @default.
- W2019094219 modified "2023-09-26" @default.
- W2019094219 title "Expression of Cytoskeletal Elements in Proliferating Cells Following Radiation Exposure" @default.
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- W2019094219 doi "https://doi.org/10.1080/09553009114551051" @default.
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