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• W2019100391 abstract "1. Absorption, excretion, tissue distribution and metabolism of the anthraquinone [14C]emodin was studied after a single oral administration (approx. 50mg/kg) to rats.2. Urinary excretion amounted to 18pm 5)% dose in 24h and to 22(pm 6)% in 72 h.3. Metabolites found in pooled urine (0-72 h) were mostly free anthraquinones (emodin and emodic acid, 16% dose); 3% was conjugated and 3% was non-extractable radioactivity.4. In 24h, 48 pm 11% and in 120 h, 68pm8% dose was excreted in the faeces, mostly in the free anthraquinone form.5. In two cannulated rats biliary excretion reached a maximum at approx. 6h and amounted to 49% dose within 15 h; 70% of biliary activity was in the form of conjugated emodin.6. The content of radioactivity in most organs decreased significantly between 3 and 5 days. In kidneys, however, the 14C activity was still equiv. to 4.33 p.p.m. emodin after five days. Mesenterium and fat tissue showed increasing 14C activity from 72 to 120 h." @default.
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• W2019100391 date "1981-01-01" @default.
• W2019100391 modified "2023-10-04" @default.
• W2019100391 title "Metabolism of [¹⁴C]emodin in the rat" @default.
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• W2019100391 doi "https://doi.org/10.3109/00498258109045294" @default.
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