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- W2019103615 abstract "Bosentan is an endothelin receptor antagonist used as a first-line treatment in pulmonary arterial hypertension (PAH). Its main adverse effect is a dose-dependent liver toxicity. CYP2C9*2 has recently been shown to be associated with hepatotoxicity in PAH patients. We conducted a nested case–control study to further explore the relationship between functional polymorphisms of gene products involved in bosentan pharmacokinetics (OATP1B1, OATP1B3, and CYP2C9) or hepatobiliary transporters affected by bosentan (ABCB11) and bosentan-induced liver toxicity. Clinical Pharmacology & Therapeutics (2014); 95 6, 583–585. doi:10.1038/clpt.2014.42" @default.
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- W2019103615 date "2014-06-01" @default.
- W2019103615 modified "2023-10-07" @default.
- W2019103615 title "CYP2C9, SLCO1B1, SLCO1B3, and ABCB11 Polymorphisms in Patients With Bosentan-Induced Liver Toxicity" @default.
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- W2019103615 doi "https://doi.org/10.1038/clpt.2014.42" @default.
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