FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019113684> ?p ?o ?g. }

• W2019113684 endingPage "1762" @default.
• W2019113684 startingPage "1753" @default.
• W2019113684 abstract "Objective: To determine the expressions of multiple genes in the subcutaneous adipose tissue of HIV-positive, highly active antiretroviral therapy (HAART)-treated patients with and without lipodystrophy. Design and methods: Real-time polymerase chain reaction was used to measure gene expressions in this cross-sectional study. Results: The messenger RNA concentrations of adipose transcription factors (peroxisome proliferator-activated receptor (PPAR) gamma and delta and sterol regulatory element binding protein 1c) were all significantly lower in the lipodystrophic than the non-lipodystrophic group. The mRNA concentration of PPAR-γ co-activator 1 (PGC-1), which regulates mitochondrial biogenesis, was lower in the lipodystrophic than the non-lipodystrophic group. The mRNA expression of lipoprotein lipase, acyl coenzyme A synthase and glucose transport protein 4 were significantly lower in the lipodystrophic than the non-lipodystrophic group, but the mRNA concentrations of fatty acid transport and binding proteins were similar in both groups. The mRNA concentrations of IL-6 and CD45 (a common leukocyte marker) were significantly higher in the lipodystrophic than the non-lipodystrophic group. Conclusion: Multiple alterations characterize gene expression in the subcutaneous adipose tissue of patients with HAART-associated lipodystrophy compared with HIV-positive, HAART-treated patients without lipodystrophy. The low expression of transcription factors inhibits adipocyte differentiation. The low expression of PGC-1 may contribute to mitochondrial defects. In addition, IL-6 and CD45 expressions are increased, the latter implying an excessive number of cells of leukocyte origin in lipodystrophic adipose tissue. Mitochondrial injury and an excess of proinflammatory cytokines may lead to increased apoptosis. All these changes may contribute to the loss of subcutaneous fat in HAART-associated lipodystrophy." @default.
• W2019113684 created "2016-06-24" @default.
• W2019113684 creator A5017225831 @default.
• W2019113684 creator A5019553315 @default.
• W2019113684 creator A5025435359 @default.
• W2019113684 creator A5028094654 @default.
• W2019113684 creator A5028953583 @default.
• W2019113684 creator A5041729124 @default.
• W2019113684 creator A5048369934 @default.
• W2019113684 creator A5049250255 @default.
• W2019113684 creator A5054939976 @default.
• W2019113684 creator A5065650336 @default.
• W2019113684 creator A5081317523 @default.
• W2019113684 date "2003-08-01" @default.
• W2019113684 modified "2023-10-16" @default.
• W2019113684 title "Expression of adipogenic transcription factors, peroxisome proliferator-activated receptor gamma co-activator 1, IL-6 and CD45 in subcutaneous adipose tissue in lipodystrophy associated with highly active antiretroviral therapy" @default.
• W2019113684 cites W1577139444 @default.
• W2019113684 cites W1672804368 @default.
• W2019113684 cites W1975927677 @default.
• W2019113684 cites W1978724449 @default.
• W2019113684 cites W1984191109 @default.
• W2019113684 cites W1988400413 @default.
• W2019113684 cites W1989535960 @default.
• W2019113684 cites W1995481669 @default.
• W2019113684 cites W1998660799 @default.
• W2019113684 cites W2003859756 @default.
• W2019113684 cites W2008568914 @default.
• W2019113684 cites W2008632158 @default.
• W2019113684 cites W2009104414 @default.
• W2019113684 cites W2015495335 @default.
• W2019113684 cites W2017506602 @default.
• W2019113684 cites W2021693564 @default.
• W2019113684 cites W2024050954 @default.
• W2019113684 cites W2027874598 @default.
• W2019113684 cites W2028026629 @default.
• W2019113684 cites W2032026322 @default.
• W2019113684 cites W2035554684 @default.
• W2019113684 cites W2049965571 @default.
• W2019113684 cites W2053701857 @default.
• W2019113684 cites W2053765200 @default.
• W2019113684 cites W2060156800 @default.
• W2019113684 cites W2066851471 @default.
• W2019113684 cites W2068078604 @default.
• W2019113684 cites W2077217192 @default.
• W2019113684 cites W2077488136 @default.
• W2019113684 cites W2079905097 @default.
• W2019113684 cites W2080185082 @default.
• W2019113684 cites W2088407989 @default.
• W2019113684 cites W2089557883 @default.
• W2019113684 cites W2089557992 @default.
• W2019113684 cites W2091673549 @default.
• W2019113684 cites W2094091679 @default.
• W2019113684 cites W2097899015 @default.
• W2019113684 cites W2101537600 @default.
• W2019113684 cites W2107735993 @default.
• W2019113684 cites W2108551042 @default.
• W2019113684 cites W2113999599 @default.
• W2019113684 cites W2121029272 @default.
• W2019113684 cites W2122944706 @default.
• W2019113684 cites W2123652234 @default.
• W2019113684 cites W2130848023 @default.
• W2019113684 cites W2131471654 @default.
• W2019113684 cites W2139502307 @default.
• W2019113684 cites W2148134248 @default.
• W2019113684 cites W2152807050 @default.
• W2019113684 cites W2163617802 @default.
• W2019113684 cites W2164676747 @default.
• W2019113684 cites W2171715833 @default.
• W2019113684 cites W2171968999 @default.
• W2019113684 cites W2315508902 @default.
• W2019113684 cites W2318289184 @default.
• W2019113684 cites W2321741507 @default.
• W2019113684 cites W2333749627 @default.
• W2019113684 cites W4244233218 @default.
• W2019113684 doi "https://doi.org/10.1097/00002030-200308150-00004" @default.
• W2019113684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12891061" @default.
• W2019113684 hasPublicationYear "2003" @default.
• W2019113684 type Work @default.
• W2019113684 sameAs 2019113684 @default.
• W2019113684 citedByCount "114" @default.
• W2019113684 countsByYear W20191136842012 @default.
• W2019113684 countsByYear W20191136842013 @default.
• W2019113684 countsByYear W20191136842015 @default.
• W2019113684 countsByYear W20191136842017 @default.
• W2019113684 countsByYear W20191136842018 @default.
• W2019113684 countsByYear W20191136842020 @default.
• W2019113684 countsByYear W20191136842021 @default.
• W2019113684 countsByYear W20191136842022 @default.
• W2019113684 crossrefType "journal-article" @default.
• W2019113684 hasAuthorship W2019113684A5017225831 @default.
• W2019113684 hasAuthorship W2019113684A5019553315 @default.
• W2019113684 hasAuthorship W2019113684A5025435359 @default.
• W2019113684 hasAuthorship W2019113684A5028094654 @default.
• W2019113684 hasAuthorship W2019113684A5028953583 @default.
• W2019113684 hasAuthorship W2019113684A5041729124 @default.
• W2019113684 hasAuthorship W2019113684A5048369934 @default.
• W2019113684 hasAuthorship W2019113684A5049250255 @default.
• W2019113684 hasAuthorship W2019113684A5054939976 @default.

• next