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- W2019115372 abstract "Effects of flurazepam, a benzodiazepine derivative, on Ca 2+ -induced cardiostimulant contractile activity in normal Tyrode’s solution and Ca 2+ -mediated contraction in K + -rich (19–22 mM) Tyrode’s solution were investigated in electrically driven left atrial preparations isolated from guinea-pigs. In normal Tyrode’s solution, flurazepam (1×10 −6 , 1×10 −5 and 1×10 −4 M) noncompetitively shifted the dose-response curves for CaCl 2 downwards. In K + (19 m M) -rich Tyrode’s solution, flurazepam (3×10 −5 M) decreased contractile amplitude time-dependently; and after addition of CaCl 2 (final: 8 mM), contractile amplitude was increased time-dependently. In K + (19 mM)-de-polarized preparations, flurazepam (3χ10 -5 M) competitively shifted the dose-response curve for CaCl 2 rightwards. In the K + (22 mM)-depolarized isoproterenol (3.8×10 −6 M)-treated atrial preparation, flurazepam (3×10 -5 M) consistently suppressed contraction. Flurazepam (9×10 −5 M) suppressed atrial contraction in tetrodotoxin (TTX) (2×10 −5 M)-added normal Tyrode’s solution, and CaCl 2 (final: 8 mM) partially restored the contraction. These results suggest that flurazepam inhibits transmembrane Ca 2+ -influx into the atrial muscle cell." @default.
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- W2019115372 title "Ca2+-antagonistic effects of flurazepam, a benzodiazepine derivative, on isolated guinea-pig left atria." @default.
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- W2019115372 doi "https://doi.org/10.1254/jjp.33.845" @default.
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