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- W2019116720 abstract "Objective: Combined acute renal failure (ARF) and acute lung injury (ALI) is associated with significant mortality in the ICU. We have shown that kidney ischemia-reperfusion injury (IRI) causes lung leak and inflammation in rodents. To explore potential mechanisms, gene expression profiling of lung during kidney IRI was performed to identify novel candidate genes. Methods: C57BL/6J mice (∼25 gm) underwent laparotomy (sham), bilateral renal artery clamp for 60 min (IRI), or bilateral nephrectomy (BNx) as uremic controls. At 24 hours, total RNA from lung was isolated and hybridized to MG-U74A (12488 genes) GeneChips (n = 3/group) which were simultaneously analyzed by GC-RMA and SAM. Genes with lowest false discovery rate (q = 0.092%) and >50% fold change compared to sham were considered significantly affected. Results: Analysis identified 600 genes with increased expression after kidney IRI, of which 145 (24%) were also increased after BNx, and 327 genes with decreased expression, of which 123 (38%) were decreased after BNx. Therefore, 455 up-regulated and 204 down-regulated ischemia-specific candidate genes were identified. Gene ontology (GO) analysis by MAPPFinder revealed significant (Z > 1.95) up-regulation of the following biological processes:TableConclusion: Kidney IRI induces a specific transcriptomic response in the lung that is unique from global uremia. Detailed investigation of these stress-induced pathways will provide insight into the mechanisms of ischemic ARF-induced ALI." @default.
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- W2019116720 date "2006-06-01" @default.
- W2019116720 modified "2023-09-26" @default.
- W2019116720 title "IDENTIFICATION OF ISCHEMIA-SPECIFIC CANDIDATE GENES DURING ACUTE RENAL FAILURE-INDUCED LUNG INJURY" @default.
- W2019116720 doi "https://doi.org/10.1097/00024382-200606001-00108" @default.
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