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• W2019127144 abstract "<h3>Aim</h3> Keratoprosthesis (KPro) devices are prone to long-term corrosion and microbiological assault. The authors aimed to compare the inflammatory response and material dissolution properties of two candidate KPro skirt materials, hydroxyapatite (HA) and titania (TiO₂) in a simulated in vitro cornea inflammation environment. <h3>Methods</h3> Lipopolysaccharide-stimulated cytokine secretions were evaluated with human corneal fibroblasts on both HA and TiO₂. Material specimens were subjected to electrochemical and long-term incubation test with artificial tear fluid (ATF) of various acidities. Topography and surface roughness of material discs were analysed by scanning electron microscopy and atomic force microscopy. <h3>Results</h3> There were less cytokines secreted from human corneal fibroblasts seeded on TiO₂ substrates as compared with HA. TiO₂ was more resistant to the corrosion effect caused by acidic ATF in contrast to HA. Moreover, the elemental composition of TiO₂ was more stable than HA after long-term incubation with ATF. <h3>Conclusions</h3> TiO₂ is more resistant to inflammatory degradation and has a higher corrosion resistance as compared with HA, and in this regard may be a suitable material to replace HA as an osteo-odonto-keratoprosthesis skirt. This would reduce resorption rates for KPro surgery." @default.
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• W2019127144 date "2012-07-16" @default.
• W2019127144 modified "2023-10-14" @default.
• W2019127144 title "In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt" @default.
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• W2019127144 doi "https://doi.org/10.1136/bjophthalmol-2012-301633" @default.
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