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- W2019128864 abstract "Substance P, the most abundant neurokinin in the CNS, is a major modulator of the immune system. We have examined the gene expression of substance P and its receptor in human fetal brain microglia. Using reverse transcription–polymerase chain reaction and Southern blotting assay, the four isoforms of preprotachykinin-A gene transcripts (α, β, γ and δ) were detected in the microglia. The human fetal microglia produced significantly higher levels of endogenous substance P protein (640–850 pg/106 cells) than did human peripheral blood monocyte-derived macrophages (25–50 pg/106 cells), as determined by an enzyme immunoassay. Using immunohistochemical staining with an anti-substance P antibody, cell membrane substance P immunoreactivity was observed. In addition, we identified the presence of messenger RNA for neurokinin-1 receptor, a primary receptor for substance P in human fetal microglia. From these data, we propose that substance P and its receptor are biologically involved in regulating the functions of microglia, and potentially play an important role in host defense of the central nervous system." @default.
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- W2019128864 date "2000-11-01" @default.
- W2019128864 modified "2023-10-15" @default.
- W2019128864 title "Detection of substance P and its receptor in human fetal microglia" @default.
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- W2019128864 doi "https://doi.org/10.1016/s0306-4522(00)00398-5" @default.
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