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- W2019131768 abstract "The kinetics of binding for the histone-like protein TmHU (from Thermotoga maritima) to DNA is analyzed on a single molecule level by use of optical tweezers. For the reaction rate a pronounced concentration-dependence is found with an all or nothing-limit which suggests the cooperative nature of the binding-reaction. By analyzing the statistics of mechanically induced dissociation-events of TmHU from DNA multiple reaction sites are observed to become more likely with increasing TmHU concentration. This is interpreted as a hint for a secondary organizational level of the TmHU/DNA complex. The reaction rate of TmHU binding to DNA is remarkably higher than that of the HU protein from Escherichia coli which will be discussed." @default.
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- W2019131768 date "2007-07-27" @default.
- W2019131768 modified "2023-10-16" @default.
- W2019131768 title "Kinetics of TmHU binding to DNA as observed by optical tweezers" @default.
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- W2019131768 doi "https://doi.org/10.1002/jemt.20498" @default.
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