FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019141390> ?p ?o ?g. }

• W2019141390 endingPage "4408" @default.
• W2019141390 startingPage "4403" @default.
• W2019141390 abstract "Abstract Emerging studies indicate that hypothalamic hormonal signalling pathways and nutrient metabolism regulate glucose homeostasis in rodents. Although hypothalamic lactate‐sensing mechanisms have been described to lower glucose production (GP), it is currently unknown whether the hypothalamus senses lactate in the blood circulation to regulate GP and maintain glucose homeostasis in vivo . To examine whether hypothalamic sensing of circulating lactate is required to regulate GP, we infused intravenous (i.v.) lactate in the absence or presence of inhibition of central/hypothalamic lactate‐sensing mechanisms in normal rodents. Inhibition of central/hypothalamic lactate‐sensing mechanisms was achieved by three independent approaches. Tracer‐dilution methodology in combination with the pancreatic clamp technique was used to assess the effect of i.v. and central/hypothalamic administrations on glucose metabolism in vivo . In the presence of physiologically relevant increases in the levels of plasma lactate, inhibition of central lactate‐sensing mechanisms by lactate dehydrogenase inhibitor oxamate (OXA) or ATP‐sensitive potassium channels blocker glibenclamide increased GP. Furthermore, direct administration of OXA into the mediobasal hypothalamus increased GP in the presence of similar elevation of circulating lactate. Together, these data indicate that hypothalamic sensing of circulating lactate regulates GP and is required to maintain glucose homeostasis." @default.
• W2019141390 created "2016-06-24" @default.
• W2019141390 creator A5032533228 @default.
• W2019141390 creator A5035012115 @default.
• W2019141390 creator A5043831622 @default.
• W2019141390 creator A5050303972 @default.
• W2019141390 date "2009-11-01" @default.
• W2019141390 modified "2023-09-29" @default.
• W2019141390 title "Hypothalamic sensing of circulating lactate regulates glucose production" @default.
• W2019141390 cites W1963957834 @default.
• W2019141390 cites W1964532167 @default.
• W2019141390 cites W1965019847 @default.
• W2019141390 cites W1967206579 @default.
• W2019141390 cites W1971604081 @default.
• W2019141390 cites W1978248654 @default.
• W2019141390 cites W1994323704 @default.
• W2019141390 cites W2003867612 @default.
• W2019141390 cites W2011497652 @default.
• W2019141390 cites W2014595943 @default.
• W2019141390 cites W2016850962 @default.
• W2019141390 cites W2017709986 @default.
• W2019141390 cites W2022362070 @default.
• W2019141390 cites W2024138018 @default.
• W2019141390 cites W2028035581 @default.
• W2019141390 cites W2031517095 @default.
• W2019141390 cites W2043394717 @default.
• W2019141390 cites W2052985185 @default.
• W2019141390 cites W2067378751 @default.
• W2019141390 cites W2072556905 @default.
• W2019141390 cites W2091988898 @default.
• W2019141390 cites W2093559498 @default.
• W2019141390 cites W2099584401 @default.
• W2019141390 cites W2105897677 @default.
• W2019141390 cites W2109820048 @default.
• W2019141390 cites W2148366635 @default.
• W2019141390 cites W2156594005 @default.
• W2019141390 cites W2160384513 @default.
• W2019141390 cites W2228873091 @default.
• W2019141390 cites W2334945609 @default.
• W2019141390 doi "https://doi.org/10.1111/j.1582-4934.2008.00596.x" @default.
• W2019141390 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4515055" @default.
• W2019141390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19040414" @default.
• W2019141390 hasPublicationYear "2009" @default.
• W2019141390 type Work @default.
• W2019141390 sameAs 2019141390 @default.
• W2019141390 citedByCount "25" @default.
• W2019141390 countsByYear W20191413902013 @default.
• W2019141390 countsByYear W20191413902014 @default.
• W2019141390 countsByYear W20191413902015 @default.
• W2019141390 countsByYear W20191413902016 @default.
• W2019141390 countsByYear W20191413902017 @default.
• W2019141390 countsByYear W20191413902019 @default.
• W2019141390 countsByYear W20191413902020 @default.
• W2019141390 countsByYear W20191413902021 @default.
• W2019141390 countsByYear W20191413902022 @default.
• W2019141390 countsByYear W20191413902023 @default.
• W2019141390 crossrefType "journal-article" @default.
• W2019141390 hasAuthorship W2019141390A5032533228 @default.
• W2019141390 hasAuthorship W2019141390A5035012115 @default.
• W2019141390 hasAuthorship W2019141390A5043831622 @default.
• W2019141390 hasAuthorship W2019141390A5050303972 @default.
• W2019141390 hasBestOaLocation W20191413901 @default.
• W2019141390 hasConcept C126322002 @default.
• W2019141390 hasConcept C134018914 @default.
• W2019141390 hasConcept C150903083 @default.
• W2019141390 hasConcept C17093226 @default.
• W2019141390 hasConcept C181199279 @default.
• W2019141390 hasConcept C185592680 @default.
• W2019141390 hasConcept C207001950 @default.
• W2019141390 hasConcept C2777003273 @default.
• W2019141390 hasConcept C2777318727 @default.
• W2019141390 hasConcept C2777391703 @default.
• W2019141390 hasConcept C2779306644 @default.
• W2019141390 hasConcept C3018667095 @default.
• W2019141390 hasConcept C55493867 @default.
• W2019141390 hasConcept C63645605 @default.
• W2019141390 hasConcept C71924100 @default.
• W2019141390 hasConcept C86803240 @default.
• W2019141390 hasConceptScore W2019141390C126322002 @default.
• W2019141390 hasConceptScore W2019141390C134018914 @default.
• W2019141390 hasConceptScore W2019141390C150903083 @default.
• W2019141390 hasConceptScore W2019141390C17093226 @default.
• W2019141390 hasConceptScore W2019141390C181199279 @default.
• W2019141390 hasConceptScore W2019141390C185592680 @default.
• W2019141390 hasConceptScore W2019141390C207001950 @default.
• W2019141390 hasConceptScore W2019141390C2777003273 @default.
• W2019141390 hasConceptScore W2019141390C2777318727 @default.
• W2019141390 hasConceptScore W2019141390C2777391703 @default.
• W2019141390 hasConceptScore W2019141390C2779306644 @default.
• W2019141390 hasConceptScore W2019141390C3018667095 @default.
• W2019141390 hasConceptScore W2019141390C55493867 @default.
• W2019141390 hasConceptScore W2019141390C63645605 @default.
• W2019141390 hasConceptScore W2019141390C71924100 @default.
• W2019141390 hasConceptScore W2019141390C86803240 @default.
• W2019141390 hasIssue "11-12" @default.
• W2019141390 hasLocation W20191413901 @default.
• W2019141390 hasLocation W20191413902 @default.
• W2019141390 hasLocation W20191413903 @default.

• next