Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019146886> ?p ?o ?g. }
- W2019146886 endingPage "668" @default.
- W2019146886 startingPage "661" @default.
- W2019146886 abstract "This investigation was designed to determine whether the five genes, CLC, DSG3, EMP3, S100A2 and SLPI, are differentially expressed in keratoconus, as indicated from another study.Gene expression was monitored using quantitative real-time PCR on 14 keratoconus samples and 16 controls, and normalized to GAPDH and B2M. The DSG3, S100A2, and SLPI proteins were quantified by Western blotting, and the cellular localization was determined by immunohistochemistry. One of the genes, CLC, was reduced in gene expression and its four exons were sequenced.The five genes were all differentially expressed in keratoconus (P < 0.04) and so were at least three of the encoded proteins (P = 0.009). DSG3 was expressed in association with the cell membrane of the basal and suprabasal epithelial cells, and S100A2 was expressed in the nucleus and cytoplasm, often as intracellular granules. Two SNPs (rs374185 and rs384138) were observed in the CLC gene, each with an allele frequency of 68%. No other mutations were detected.The five genes, and three of the encoded proteins, were shown differentially expressed between a group of keratoconus patients and a reference group using different techniques. These alterations, in combination with earlier findings, strongly demonstrate the genes to be involved in the corneal disease. We suggest the unambiguously expressed DSG3 protein to be used as a marker for keratoconus." @default.
- W2019146886 created "2016-06-24" @default.
- W2019146886 creator A5002049307 @default.
- W2019146886 creator A5007467209 @default.
- W2019146886 creator A5027336843 @default.
- W2019146886 creator A5079934811 @default.
- W2019146886 creator A5082168771 @default.
- W2019146886 creator A5082251486 @default.
- W2019146886 date "2005-08-01" @default.
- W2019146886 modified "2023-09-24" @default.
- W2019146886 title "Altered Expression of CLC, DSG3, EMP3, S100A2, and SLPI in Corneal Epithelium from Keratoconus Patients" @default.
- W2019146886 cites W1488482313 @default.
- W2019146886 cites W1572867882 @default.
- W2019146886 cites W1764196602 @default.
- W2019146886 cites W1907946825 @default.
- W2019146886 cites W1960127159 @default.
- W2019146886 cites W1977146380 @default.
- W2019146886 cites W1980136660 @default.
- W2019146886 cites W1983895626 @default.
- W2019146886 cites W1986080495 @default.
- W2019146886 cites W1989949699 @default.
- W2019146886 cites W1990852282 @default.
- W2019146886 cites W1995460878 @default.
- W2019146886 cites W1999374995 @default.
- W2019146886 cites W2004554807 @default.
- W2019146886 cites W2006296875 @default.
- W2019146886 cites W2007147082 @default.
- W2019146886 cites W2015836613 @default.
- W2019146886 cites W2018155538 @default.
- W2019146886 cites W2024882709 @default.
- W2019146886 cites W2033343077 @default.
- W2019146886 cites W2049145125 @default.
- W2019146886 cites W2059595437 @default.
- W2019146886 cites W2060331274 @default.
- W2019146886 cites W2060842588 @default.
- W2019146886 cites W2067538132 @default.
- W2019146886 cites W2068284474 @default.
- W2019146886 cites W2075074975 @default.
- W2019146886 cites W2075986822 @default.
- W2019146886 cites W2076919981 @default.
- W2019146886 cites W2081992480 @default.
- W2019146886 cites W2082955274 @default.
- W2019146886 cites W2090982434 @default.
- W2019146886 cites W2097643766 @default.
- W2019146886 cites W2117012616 @default.
- W2019146886 cites W2117770954 @default.
- W2019146886 cites W2117832286 @default.
- W2019146886 cites W2120035779 @default.
- W2019146886 cites W2125248412 @default.
- W2019146886 cites W2128635872 @default.
- W2019146886 cites W2133024416 @default.
- W2019146886 cites W2135598172 @default.
- W2019146886 cites W2141360208 @default.
- W2019146886 cites W2154778560 @default.
- W2019146886 cites W2157037806 @default.
- W2019146886 cites W2158401991 @default.
- W2019146886 cites W2158638119 @default.
- W2019146886 cites W2160892965 @default.
- W2019146886 cites W2165572249 @default.
- W2019146886 cites W2170989872 @default.
- W2019146886 cites W2171300323 @default.
- W2019146886 cites W2244606885 @default.
- W2019146886 cites W2317767752 @default.
- W2019146886 cites W2339419218 @default.
- W2019146886 cites W2401155587 @default.
- W2019146886 cites W2917349696 @default.
- W2019146886 cites W4248451563 @default.
- W2019146886 doi "https://doi.org/10.1097/01.ico.0000153556.59407.69" @default.
- W2019146886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16015083" @default.
- W2019146886 hasPublicationYear "2005" @default.
- W2019146886 type Work @default.
- W2019146886 sameAs 2019146886 @default.
- W2019146886 citedByCount "32" @default.
- W2019146886 countsByYear W20191468862012 @default.
- W2019146886 countsByYear W20191468862013 @default.
- W2019146886 countsByYear W20191468862014 @default.
- W2019146886 countsByYear W20191468862015 @default.
- W2019146886 countsByYear W20191468862016 @default.
- W2019146886 countsByYear W20191468862017 @default.
- W2019146886 countsByYear W20191468862018 @default.
- W2019146886 countsByYear W20191468862019 @default.
- W2019146886 countsByYear W20191468862021 @default.
- W2019146886 crossrefType "journal-article" @default.
- W2019146886 hasAuthorship W2019146886A5002049307 @default.
- W2019146886 hasAuthorship W2019146886A5007467209 @default.
- W2019146886 hasAuthorship W2019146886A5027336843 @default.
- W2019146886 hasAuthorship W2019146886A5079934811 @default.
- W2019146886 hasAuthorship W2019146886A5082168771 @default.
- W2019146886 hasAuthorship W2019146886A5082251486 @default.
- W2019146886 hasConcept C104317684 @default.
- W2019146886 hasConcept C150194340 @default.
- W2019146886 hasConcept C153911025 @default.
- W2019146886 hasConcept C169760540 @default.
- W2019146886 hasConcept C2776882836 @default.
- W2019146886 hasConcept C2778918178 @default.
- W2019146886 hasConcept C2779257441 @default.
- W2019146886 hasConcept C529295009 @default.
- W2019146886 hasConcept C54355233 @default.