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- W2019149099 abstract "Abstract Two prostaglandin antagonists, polyphloretin phosphate (PPP) and 7-oxa-13-prostynoic acid (EC-I-148) were examined for their ability and selectivity to block the vasoactive actions of prostaglandin E 2 and 5-hydroxytryptamine on isolated human umbilical arteries. Polyphloretin phosphate was found to be a weak antagonist of prostaglandin E 2 and exhibited a low degree of selectivity since responses to 5-hydroxytryptamine were also blocked. EC-I-148 (3.25 × 10 −5 M ) demonstrated a strong and selective antagonism to the contractions produced by prostaglandin E 2 because contractions to 5-hydroxytryptamine were not altered. EC-I-148 contracted umbilical artery strips in concentrations which antagonized responses to PGE 2 ." @default.
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- W2019149099 date "1973-06-01" @default.
- W2019149099 modified "2023-09-25" @default.
- W2019149099 title "Effect of polyphloretin phosphate and 7-oxa-13-prostynoic acid on the vasoactive actions of prostaglandin E2 and 5-hydroxytryptamine on isolated human umbilical arteries" @default.
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- W2019149099 doi "https://doi.org/10.1016/0090-6980(73)90015-4" @default.
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