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• W2019150306 abstract "In the past decade, several transcription factors critical for pancreas organogenesis have been identified. Despite this success, many of the factors necessary for proper islet morphogenesis and function remain uncharacterized. Previous studies have shown that transgenic over-expression of the transcription factor Hnf6 specifically in the pancreatic endocrine cell lineage resulted in disruptions in islet morphogenesis, including dysfunctional endocrine cell sorting, increased individual islet size, increased number of peripheral endocrine cell types, and failure of islets to migrate away from the ductal epithelium. The mechanisms whereby maintained Hnf6 causes defects in islet morphogenesis have yet to be elucidated.We exploited the dysmorphic islets in Hnf6 transgenic animals as a tool to identify factors important for islet morphogenesis. Genome-wide microarray analysis was used to identify differences in the gene expression profiles of late gestation and early postnatal total pancreas tissue from wild type and Hnf6 transgenic animals. Here we report the identification of genes with an altered expression in Hnf6 transgenic animals and highlight factors with potential importance in islet morphogenesis. Importantly, gene products involved in cell adhesion, cell migration, ECM remodeling and proliferation were found to be altered in Hnf6 transgenic pancreata, revealing specific candidates that can now be analyzed directly for their role in these processes during islet development.This study provides a unique dataset that can act as a starting point for other investigators to explore the role of the identified genes in pancreatogenesis, islet morphogenesis and mature beta cell function." @default.
• W2019150306 created "2016-06-24" @default.
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• W2019150306 date "2008-02-20" @default.
• W2019150306 modified "2023-10-10" @default.
• W2019150306 title "Gene Expression Profiling of a Mouse Model of Pancreatic Islet Dysmorphogenesis" @default.
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• W2019150306 cites W1721336579 @default.
• W2019150306 cites W1830287761 @default.
• W2019150306 cites W1958779837 @default.
• W2019150306 cites W1965893213 @default.
• W2019150306 cites W1968863211 @default.
• W2019150306 cites W1969459168 @default.
• W2019150306 cites W1969563910 @default.
• W2019150306 cites W1972051140 @default.
• W2019150306 cites W1980797966 @default.
• W2019150306 cites W1988051064 @default.
• W2019150306 cites W1988765975 @default.
• W2019150306 cites W1995532669 @default.
• W2019150306 cites W2003207229 @default.
• W2019150306 cites W2004697957 @default.
• W2019150306 cites W2005463323 @default.
• W2019150306 cites W2005688198 @default.
• W2019150306 cites W2008933976 @default.
• W2019150306 cites W2011478420 @default.
• W2019150306 cites W2012053529 @default.
• W2019150306 cites W2012455440 @default.
• W2019150306 cites W2016207732 @default.
• W2019150306 cites W2018262559 @default.
• W2019150306 cites W2023830997 @default.
• W2019150306 cites W2025397278 @default.
• W2019150306 cites W2025458645 @default.
• W2019150306 cites W2025591931 @default.
• W2019150306 cites W2033045615 @default.
• W2019150306 cites W2035621553 @default.
• W2019150306 cites W2047178578 @default.
• W2019150306 cites W2060623164 @default.
• W2019150306 cites W2064520670 @default.
• W2019150306 cites W2064756027 @default.
• W2019150306 cites W2073649301 @default.
• W2019150306 cites W2081685854 @default.
• W2019150306 cites W2084918744 @default.
• W2019150306 cites W2089328941 @default.
• W2019150306 cites W2089978707 @default.
• W2019150306 cites W2095094506 @default.
• W2019150306 cites W2097352432 @default.
• W2019150306 cites W2105736832 @default.
• W2019150306 cites W2106437575 @default.
• W2019150306 cites W2107854932 @default.
• W2019150306 cites W2110447217 @default.
• W2019150306 cites W2111404063 @default.
• W2019150306 cites W2114884455 @default.
• W2019150306 cites W2117532375 @default.
• W2019150306 cites W2117602113 @default.
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• W2019150306 cites W2124584525 @default.
• W2019150306 cites W2125579246 @default.
• W2019150306 cites W2127791191 @default.
• W2019150306 cites W2130650643 @default.
• W2019150306 cites W2131622047 @default.
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• W2019150306 cites W2133260492 @default.
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• W2019150306 cites W2141365044 @default.
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• W2019150306 cites W2144924187 @default.
• W2019150306 cites W2145639699 @default.
• W2019150306 cites W2146127531 @default.
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• W2019150306 cites W2166051507 @default.
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• W2019150306 doi "https://doi.org/10.1371/journal.pone.0001611" @default.
• W2019150306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2249940" @default.
• W2019150306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18297134" @default.
• W2019150306 hasPublicationYear "2008" @default.
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