Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019154144> ?p ?o ?g. }
- W2019154144 endingPage "905" @default.
- W2019154144 startingPage "899" @default.
- W2019154144 abstract "Glioblastoma multiforme (GBM) is a devastating disease and the most lethal of adult brain tumors. Treatment is based on surgery, radiotherapy and chemotherapy by oral temozolomide (TMZ), which is the most potent chemotherapy agent for the treatment of GBM. Despite TMZ efficiency, the prognosis of these tumors remains poor. This is because of inherent or acquired resistance of glioma tumor cells to TMZ. This resistance is caused by DNA repair enzyme activity, overexpression of epidermal growth factor receptor (EGFR), galectin-1, murine double minute 2 (Mdm2), p53 and phosphatase and tensin homolog (PTEN) mutations. Many strategies to overcome this resistance have been developed. In this review, we will describe the main mechanisms of GBM resistance to TMZ and different strategies developed to reverse the phenotype of these tumor cells. Finally, we will discuss the drawbacks and limitations of these strategies." @default.
- W2019154144 created "2016-06-24" @default.
- W2019154144 creator A5054163652 @default.
- W2019154144 creator A5066854710 @default.
- W2019154144 creator A5076342061 @default.
- W2019154144 date "2015-07-01" @default.
- W2019154144 modified "2023-10-17" @default.
- W2019154144 title "Toward an effective strategy in glioblastoma treatment. Part I: resistance mechanisms and strategies to overcome resistance of glioblastoma to temozolomide" @default.
- W2019154144 cites W1585236421 @default.
- W2019154144 cites W1965205681 @default.
- W2019154144 cites W1968091639 @default.
- W2019154144 cites W1971344938 @default.
- W2019154144 cites W1972791877 @default.
- W2019154144 cites W1972989638 @default.
- W2019154144 cites W1986183552 @default.
- W2019154144 cites W1990337776 @default.
- W2019154144 cites W1995502732 @default.
- W2019154144 cites W2010511761 @default.
- W2019154144 cites W2011279915 @default.
- W2019154144 cites W2012071848 @default.
- W2019154144 cites W2015805460 @default.
- W2019154144 cites W2018776569 @default.
- W2019154144 cites W2025515800 @default.
- W2019154144 cites W2028119906 @default.
- W2019154144 cites W2029617353 @default.
- W2019154144 cites W2031252637 @default.
- W2019154144 cites W2037821829 @default.
- W2019154144 cites W2040234559 @default.
- W2019154144 cites W2042484101 @default.
- W2019154144 cites W2046148841 @default.
- W2019154144 cites W2056002970 @default.
- W2019154144 cites W2058858243 @default.
- W2019154144 cites W2064647593 @default.
- W2019154144 cites W2065136628 @default.
- W2019154144 cites W2066740999 @default.
- W2019154144 cites W2067751798 @default.
- W2019154144 cites W2070909392 @default.
- W2019154144 cites W2077524564 @default.
- W2019154144 cites W2079203845 @default.
- W2019154144 cites W2081297751 @default.
- W2019154144 cites W2092675732 @default.
- W2019154144 cites W2094144162 @default.
- W2019154144 cites W2096287682 @default.
- W2019154144 cites W2097478662 @default.
- W2019154144 cites W2097933346 @default.
- W2019154144 cites W2099551830 @default.
- W2019154144 cites W2101057168 @default.
- W2019154144 cites W2105100844 @default.
- W2019154144 cites W2108966286 @default.
- W2019154144 cites W2109512616 @default.
- W2019154144 cites W2113370608 @default.
- W2019154144 cites W2119312052 @default.
- W2019154144 cites W2121493901 @default.
- W2019154144 cites W2129141930 @default.
- W2019154144 cites W2130625073 @default.
- W2019154144 cites W2132279561 @default.
- W2019154144 cites W2133198620 @default.
- W2019154144 cites W2135838271 @default.
- W2019154144 cites W2136734008 @default.
- W2019154144 cites W2137382956 @default.
- W2019154144 cites W2143983454 @default.
- W2019154144 cites W2144881353 @default.
- W2019154144 cites W2147696493 @default.
- W2019154144 cites W2151431383 @default.
- W2019154144 cites W2153682544 @default.
- W2019154144 cites W2153737934 @default.
- W2019154144 cites W2157672076 @default.
- W2019154144 cites W2158096599 @default.
- W2019154144 cites W2158649478 @default.
- W2019154144 cites W2158681922 @default.
- W2019154144 cites W2165254737 @default.
- W2019154144 cites W2165425627 @default.
- W2019154144 cites W2322386893 @default.
- W2019154144 cites W2328946792 @default.
- W2019154144 cites W2329341179 @default.
- W2019154144 cites W4244279664 @default.
- W2019154144 doi "https://doi.org/10.1016/j.drudis.2015.02.011" @default.
- W2019154144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25744176" @default.
- W2019154144 hasPublicationYear "2015" @default.
- W2019154144 type Work @default.
- W2019154144 sameAs 2019154144 @default.
- W2019154144 citedByCount "179" @default.
- W2019154144 countsByYear W20191541442016 @default.
- W2019154144 countsByYear W20191541442017 @default.
- W2019154144 countsByYear W20191541442018 @default.
- W2019154144 countsByYear W20191541442019 @default.
- W2019154144 countsByYear W20191541442020 @default.
- W2019154144 countsByYear W20191541442021 @default.
- W2019154144 countsByYear W20191541442022 @default.
- W2019154144 countsByYear W20191541442023 @default.
- W2019154144 crossrefType "journal-article" @default.
- W2019154144 hasAuthorship W2019154144A5054163652 @default.
- W2019154144 hasAuthorship W2019154144A5066854710 @default.
- W2019154144 hasAuthorship W2019154144A5076342061 @default.
- W2019154144 hasBestOaLocation W20191541442 @default.
- W2019154144 hasConcept C126322002 @default.
- W2019154144 hasConcept C142724271 @default.
- W2019154144 hasConcept C190283241 @default.