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- W2019160131 abstract "The BCR-ABL gene plays a central role in the pathogenesis of chronic myelogenous leukemia. Despite a detailed understanding of the regions of BCR and ABL required for transformation by BCR-ABL, little is known about the signalling pathway by which BCR-ABL causes transformation. The nuclear oncogene c-myc plays a critical role in BCR-ABL transformation. Levels of c-myc RNA are high in cells transformed by BCR-ABL, and overexpression of dominant negative forms of myc blocks transformation by BCR-ABL. These findings suggest that myc may be a useful therapeutic target in BCR-ABL-related leukemias." @default.
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- W2019160131 date "1993-01-01" @default.
- W2019160131 modified "2023-10-16" @default.
- W2019160131 title "The Role of MYC in Transformation by BCR-ABL" @default.
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- W2019160131 doi "https://doi.org/10.3109/10428199309047862" @default.
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