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- W2019161714 abstract "Anticoccidial activity of 16 drugs against Eimeria tenella was studied in cell cultures. Compounds active at 100 μg/ml or less were ethopabate, amprolium, monensin, nicarbazin, glycarbylamide, robenidine, zoalene, sulfamethazine, nitrofurazone, decoquinate, clopidol, aklomide, buquinolate, methyl benzoquate, and nitromide. Roxarsone was not active at 100 μg/ml. One level of each of nine compounds was selected for addition-withdrawal studies with suppression of development to second generation schizonts 96 hr postinoculation of sporozoites used as an endpoint of activity. Drugs were added to cultures 24, 48 or 72 hr or were added at 0 hr and withdrawn 24, 48 or 72 hr after introduction of sporozoites.Clopidol, zoalene, sulfamethazine, glycarbylamide, and nicarbazin delayed development, roughly equivalent to the time the compound was in the culture, even when compounds were withdrawn at 24 or 48 hr. Withdrawal of nicarbazin, glycarbylamide, and zoalene 72 hr after inoculation of sporozoites allowed some development of small immature schizonts of the first generation. A delay in addition of anti-coccidials until 24 hr did not affect the observed endpoint with any compounds except clopidol and glycarbylamide. When compounds were added 48 hr postinoculation of sporozoites, the activity of amprolium, glycarbylamide, sulfamethazine, and zoalene was not detected. Only with monensin was activity demonstrable when added at 72 hr.This study demonstrated that in vitro techniques can be used not only to titrate the activity of anticoccidial drugs and identify the stage of development where the drug is most active, but to determine coccidiocidal versus coccidiostatic actvity as well." @default.
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- W2019161714 date "1954-01-01" @default.
- W2019161714 modified "2023-10-01" @default.
- W2019161714 title "The effect of sodium sulphaquinoxaline and sodium sulphamezathine in interrupted schedules of treatment on the development of Eimeria tenella" @default.
- W2019161714 cites W2004803380 @default.
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- W2019161714 doi "https://doi.org/10.1016/s0368-1742(54)80010-5" @default.
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