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- W2019166253 abstract "In the search for bioactive natural products from edible mushrooms, we have investigated the fruiting body of Agrocybe aegerita. The methanol extract of this mushroom yielded a fatty acid fraction (FAF), along with palmitic acid (1), ergosterol (2), 5,8-epidioxy-ergosta-6,22-dien-3β-ol (3), mannitol (4) and trehalose (5). The composition of FAF was confirmed by GC-MS and by comparison to the retention values of authentic samples of palmitic, stearic, oleic and linoleic acids. The structures of 1–5 were established using spectroscopic methods. FAF and compounds 1–3 showed cyclooxygenase (COX) enzyme inhibitory and antioxidant activities. The inhibition values of liposome peroxidation by FAF, compounds 1 and 2 at 100 μg/ml were 75, 45, and 43%, respectively. The inhibition values of COX-I enzyme by FAF and 1–3 at 100 μg/ml were 80, 39, 19, and 57%, respectively. Similarly, COX-II enzyme activity was reduced by FAF and 1–3 at 100 μg/ml with values of 88, 45, 28, and 22%, respectively. Compounds 1, 3 and fatty acids were isolated here for the first time from the fruiting body of A. aegerita." @default.
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- W2019166253 date "2003-01-01" @default.
- W2019166253 modified "2023-09-27" @default.
- W2019166253 title "Cyclooxygenase inhibitory and antioxidant compounds from the fruiting body of an edible mushroom, Agrocybe aegerita" @default.
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- W2019166253 doi "https://doi.org/10.1078/0944-7113-00272" @default.
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