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- W2019173313 abstract "Yeast have been extensively used to model aspects of protein folding diseases, yielding novel mechanistic insights and identifying promising candidate therapeutic targets. In particular, the neurodegenerative disorder Huntington disease (HD), which is caused by the abnormal expansion of a polyglutamine tract in the huntingtin (htt) protein, has been widely studied in yeast. This work has led to the identification of several promising therapeutic targets and compounds that have been validated in mammalian cells, Drosophila and rodent models of HD. Here we discuss the development of yeast models of mutant htt toxicity and misfolding, as well as the mechanistic insights gleaned from this simple model. The role of yeast prions in the toxicity/misfolding of mutant htt is also highlighted. Furthermore, we provide an overview of the application of HD yeast models in both genetic and chemical screens, and the fruitful results obtained from these approaches. Finally, we discuss the future of yeast in neurodegenerative research, in the context of HD and other diseases." @default.
- W2019173313 created "2016-06-24" @default.
- W2019173313 creator A5018606384 @default.
- W2019173313 creator A5036156104 @default.
- W2019173313 date "2011-10-01" @default.
- W2019173313 modified "2023-10-16" @default.
- W2019173313 title "Modeling Huntington disease in yeast: Perspectives and future directions" @default.
- W2019173313 cites W1498240733 @default.
- W2019173313 cites W1547033864 @default.
- W2019173313 cites W1572968198 @default.
- W2019173313 cites W1583328975 @default.
- W2019173313 cites W1965084649 @default.
- W2019173313 cites W1965909831 @default.
- W2019173313 cites W1968060296 @default.
- W2019173313 cites W1971323868 @default.
- W2019173313 cites W1974769584 @default.
- W2019173313 cites W1978794287 @default.
- W2019173313 cites W1979182028 @default.
- W2019173313 cites W1980675329 @default.
- W2019173313 cites W1984434130 @default.
- W2019173313 cites W1985474993 @default.
- W2019173313 cites W1987072487 @default.
- W2019173313 cites W1989150559 @default.
- W2019173313 cites W1990286385 @default.
- W2019173313 cites W1992150557 @default.
- W2019173313 cites W1993938423 @default.
- W2019173313 cites W1995181798 @default.
- W2019173313 cites W1996935079 @default.
- W2019173313 cites W1997369314 @default.
- W2019173313 cites W2001283152 @default.
- W2019173313 cites W2005982725 @default.
- W2019173313 cites W2007247762 @default.
- W2019173313 cites W2007719003 @default.
- W2019173313 cites W2009568691 @default.
- W2019173313 cites W2010561560 @default.
- W2019173313 cites W2012218517 @default.
- W2019173313 cites W2013754033 @default.
- W2019173313 cites W2014011193 @default.
- W2019173313 cites W2014882369 @default.
- W2019173313 cites W2017421169 @default.
- W2019173313 cites W2019129236 @default.
- W2019173313 cites W2020159880 @default.
- W2019173313 cites W2020295900 @default.
- W2019173313 cites W2023805910 @default.
- W2019173313 cites W2040308828 @default.
- W2019173313 cites W2043676526 @default.
- W2019173313 cites W2045685992 @default.
- W2019173313 cites W2049877526 @default.
- W2019173313 cites W2058387632 @default.
- W2019173313 cites W2058546459 @default.
- W2019173313 cites W2059014219 @default.
- W2019173313 cites W2061151435 @default.
- W2019173313 cites W2062102056 @default.
- W2019173313 cites W2065144533 @default.
- W2019173313 cites W2066024683 @default.
- W2019173313 cites W2066755688 @default.
- W2019173313 cites W2067083561 @default.
- W2019173313 cites W2068275936 @default.
- W2019173313 cites W2068324161 @default.
- W2019173313 cites W2073162592 @default.
- W2019173313 cites W2073687064 @default.
- W2019173313 cites W2078771540 @default.
- W2019173313 cites W2079250951 @default.
- W2019173313 cites W2079470515 @default.
- W2019173313 cites W2080918762 @default.
- W2019173313 cites W2082313673 @default.
- W2019173313 cites W2083907721 @default.
- W2019173313 cites W2084833888 @default.
- W2019173313 cites W2085066990 @default.
- W2019173313 cites W2085999461 @default.
- W2019173313 cites W2091214947 @default.
- W2019173313 cites W2094798108 @default.
- W2019173313 cites W2099685145 @default.
- W2019173313 cites W2101180349 @default.
- W2019173313 cites W2103675937 @default.
- W2019173313 cites W2105348268 @default.
- W2019173313 cites W2106200048 @default.
- W2019173313 cites W2107892061 @default.
- W2019173313 cites W2108605108 @default.
- W2019173313 cites W2111923136 @default.
- W2019173313 cites W2112335210 @default.
- W2019173313 cites W2116769005 @default.
- W2019173313 cites W2118546680 @default.
- W2019173313 cites W2118729812 @default.
- W2019173313 cites W2120181899 @default.
- W2019173313 cites W2120355642 @default.
- W2019173313 cites W2128587253 @default.
- W2019173313 cites W2128674001 @default.
- W2019173313 cites W2130399516 @default.
- W2019173313 cites W2131926693 @default.
- W2019173313 cites W2132404134 @default.
- W2019173313 cites W2132904521 @default.
- W2019173313 cites W2133102806 @default.
- W2019173313 cites W2135783352 @default.
- W2019173313 cites W2136303131 @default.
- W2019173313 cites W2136714530 @default.
- W2019173313 cites W2138506733 @default.
- W2019173313 cites W2140518858 @default.