FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019180838> ?p ?o ?g. }

• W2019180838 endingPage "1282" @default.
• W2019180838 startingPage "1274" @default.
• W2019180838 abstract "Abstract: The functions of the extracellular domains of neural cell adhesion molecule (NCAM) have been studied extensively, whereas the roles of the cytoplasmic domains of the transmembrane forms of NCAM are less elucidated. We investigated the importance of the cytoplasmic domain of the 140-kDa NCAM isoform (cytNCAM-140) and of the 180-kDa NCAM isoform (cytNCAM-180) in NCAM-induced neurite extension by estimating NCAM-dependent neurite outgrowth from PC12-E2 cells grown in coculture with NCAM-negative or NCAM-positive fibroblasts. PC12-E2 cells were transiently transfected with expression plasmids encoding cytNCAM-140, cytNCAM-180, the constitutively active form of the mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase kinase (MEK2), and the enhanced variant of the green fluorescent protein (EGFP). EGFP expression was used for identification of transfected cells. We found that expression of cytNCAM-180 had no effect on NCAM-stimulated neuritogenesis, whereas expression of cytNCAM-140 strongly inhibited this process. However, if MEK2 was expressed concomitantly with cytNCAM-140, neurite outgrowth was rescued, indicating that cytNCAM-140 is involved in signaling via the Ras-MAP kinase pathway. PC12-E2 cells were subsequently transiently transfected with constructs encoding a series of fragments of cytNCAM-140 and various full-length cytNCAM-140 mutants, and the residues Thr-Glu-Val-Lys-Thr (839-843) were identified as essential in NCAM-stimulated neuritogenesis. The combined substitution of Glu840 and Lys842 with Ala abrogated the effect of the construct, assigning a critical role to these two residues." @default.
• W2019180838 created "2016-06-24" @default.
• W2019180838 creator A5002953444 @default.
• W2019180838 creator A5003083788 @default.
• W2019180838 creator A5064943875 @default.
• W2019180838 creator A5073327202 @default.
• W2019180838 date "2002-12-11" @default.
• W2019180838 modified "2023-09-30" @default.
• W2019180838 title "Identification of an Amino Acid Sequence Motif in the Cytoplasmic Domain of the NCAM-140 kDa Isoform Essential for Its Neuritogenic Activity" @default.
• W2019180838 cites W1540348237 @default.
• W2019180838 cites W1597676455 @default.
• W2019180838 cites W1599428638 @default.
• W2019180838 cites W1817318311 @default.
• W2019180838 cites W1964027828 @default.
• W2019180838 cites W1965389461 @default.
• W2019180838 cites W1972575806 @default.
• W2019180838 cites W1975369357 @default.
• W2019180838 cites W1977780888 @default.
• W2019180838 cites W1991764034 @default.
• W2019180838 cites W1995622454 @default.
• W2019180838 cites W2000252657 @default.
• W2019180838 cites W2001433296 @default.
• W2019180838 cites W2011308923 @default.
• W2019180838 cites W2013781426 @default.
• W2019180838 cites W2014892312 @default.
• W2019180838 cites W2023524874 @default.
• W2019180838 cites W2035791207 @default.
• W2019180838 cites W2042431388 @default.
• W2019180838 cites W2054261848 @default.
• W2019180838 cites W2067495948 @default.
• W2019180838 cites W2067707319 @default.
• W2019180838 cites W2068020196 @default.
• W2019180838 cites W2068179546 @default.
• W2019180838 cites W2069221168 @default.
• W2019180838 cites W2082289133 @default.
• W2019180838 cites W2083116072 @default.
• W2019180838 cites W2083948102 @default.
• W2019180838 cites W2085767178 @default.
• W2019180838 cites W2089559330 @default.
• W2019180838 cites W2092079020 @default.
• W2019180838 cites W2098610794 @default.
• W2019180838 cites W2113429767 @default.
• W2019180838 cites W2127500378 @default.
• W2019180838 cites W2134100234 @default.
• W2019180838 cites W2138259221 @default.
• W2019180838 cites W2150980909 @default.
• W2019180838 cites W2166701612 @default.
• W2019180838 cites W2171960232 @default.
• W2019180838 cites W2412732533 @default.
• W2019180838 cites W249315217 @default.
• W2019180838 cites W341849362 @default.
• W2019180838 doi "https://doi.org/10.1046/j.1471-4159.2000.751274.x" @default.
• W2019180838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10936211" @default.
• W2019180838 hasPublicationYear "2002" @default.
• W2019180838 type Work @default.
• W2019180838 sameAs 2019180838 @default.
• W2019180838 citedByCount "35" @default.
• W2019180838 countsByYear W20191808382016 @default.
• W2019180838 countsByYear W20191808382017 @default.
• W2019180838 countsByYear W20191808382022 @default.
• W2019180838 crossrefType "journal-article" @default.
• W2019180838 hasAuthorship W2019180838A5002953444 @default.
• W2019180838 hasAuthorship W2019180838A5003083788 @default.
• W2019180838 hasAuthorship W2019180838A5064943875 @default.
• W2019180838 hasAuthorship W2019180838A5073327202 @default.
• W2019180838 hasBestOaLocation W20191808381 @default.
• W2019180838 hasConcept C104317684 @default.
• W2019180838 hasConcept C113246987 @default.
• W2019180838 hasConcept C122871604 @default.
• W2019180838 hasConcept C1491633281 @default.
• W2019180838 hasConcept C153911025 @default.
• W2019180838 hasConcept C170493617 @default.
• W2019180838 hasConcept C184235292 @default.
• W2019180838 hasConcept C202751555 @default.
• W2019180838 hasConcept C24530287 @default.
• W2019180838 hasConcept C53345823 @default.
• W2019180838 hasConcept C54009773 @default.
• W2019180838 hasConcept C55493867 @default.
• W2019180838 hasConcept C62478195 @default.
• W2019180838 hasConcept C85789140 @default.
• W2019180838 hasConcept C86803240 @default.
• W2019180838 hasConcept C95444343 @default.
• W2019180838 hasConceptScore W2019180838C104317684 @default.
• W2019180838 hasConceptScore W2019180838C113246987 @default.
• W2019180838 hasConceptScore W2019180838C122871604 @default.
• W2019180838 hasConceptScore W2019180838C1491633281 @default.
• W2019180838 hasConceptScore W2019180838C153911025 @default.
• W2019180838 hasConceptScore W2019180838C170493617 @default.
• W2019180838 hasConceptScore W2019180838C184235292 @default.
• W2019180838 hasConceptScore W2019180838C202751555 @default.
• W2019180838 hasConceptScore W2019180838C24530287 @default.
• W2019180838 hasConceptScore W2019180838C53345823 @default.
• W2019180838 hasConceptScore W2019180838C54009773 @default.
• W2019180838 hasConceptScore W2019180838C55493867 @default.
• W2019180838 hasConceptScore W2019180838C62478195 @default.
• W2019180838 hasConceptScore W2019180838C85789140 @default.
• W2019180838 hasConceptScore W2019180838C86803240 @default.
• W2019180838 hasConceptScore W2019180838C95444343 @default.

• next