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- W2019182012 abstract "1 The Ca2+ channel subtypes of the autonomic nerves of guinea-pig atria were elucidated by monitoring the effects of specific Ca2+ channel blockers on the negative and positive inotropic responses associated respectively, with stimulation of the parasympathetic and sympathetic nerves. 2 In left atria paced at 2–4 Hz, the negative inotropic effect induced by field stimulation of parasympathetic nerves (in the presence of propranolol) was abolished by ω-conotoxin MVIIC, a blocker of N-type and OPQ subfamily Ca2+ channels. ω-Conotoxin GVIA (an N-type blocker), ω-agatoxin IVA (a P-type blocker), nifedipine (an L-type blocker) and Ni2+ (a T- and R-type blocker) were much less effective. 3 The positive inotropic response resulting from field stimulation of the sympathetic nerves (in the presence of atropine) was abolished by both ω-conotoxins, while ω-agatoxin IVA, nifedipine and Ni2+ were ineffective. 4 In the spontaneously beating right atria, the early negative inotropic effect produced by 1,1-dimethyl-4-phenylpiperazinium was abolished by ω-conotoxin MVIIC; whereas the late positive inotropic effect was partially reduced, but not abolished, by a high concentration of ω-conotoxin GVIA. 5 None of the peptide toxins affected the chronotropic and the inotropic responses evoked by carbachol and isoprenaline. 6 These results suggested that, under physiological conditions, the release of acetylcholine from paraysmpathetic nerves is dominated by an OPQ subfamily Ca2+ channel while that of noradrenaline from sympathetic nerves is controlled by an N-type Ca2+ channel. Ligand-induced noradrenaline release appeared to recruit additional type(s) of Ca2+ channel." @default.
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- W2019182012 date "1995-09-01" @default.
- W2019182012 modified "2023-09-26" @default.
- W2019182012 title "Calcium channel subtypes for the sympathetic and parasympathetic nerves of guinea-pig atria" @default.
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- W2019182012 doi "https://doi.org/10.1111/j.1476-5381.1995.tb16375.x" @default.
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