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• W2019201831 abstract "Despite experimental evidences of the influence of the aging suppressor gene Klotho, on the modulation of endothelial nitric oxide synthase (eNOS) activity and nitric oxide (NO) production, the contribution of its variants to the phenotypic variance of plasma nitrite and nitrate (NOx) has not been addressed to date. In the present study, we aimed to determine the influence of two exonic variants, KL-VS and C1818T of Klotho, on circulating NOx levels in South Indian population. We genotyped the two Klotho KL-VS and C1818T variants in 429 healthy South Indians and measured their plasma NOx concentrations by the Griess method. Genotype frequencies were compared in subjects with low and high NOx levels. An age-specific association of the Klotho C1818T variant was found with plasma NOx levels in subjects aged > 40 years (p = 0.027); the CC homozygotes were more prevalent in the low compared to the high plasma NOx group. However, the variant was not associated with plasma NOx levels in subjects aged ≤ 40 years (p = 0.799). The KL-VS variant did not have any influence on plasma NOx status (p = 0.260). Our results suggest that the effect of Klotho C1818T variant on levels of plasma NOx becomes pronounced with age probably implying the adaptive capability of Klotho alleles to meet the age-related increasing physiological load." @default.
• W2019201831 created "2016-06-24" @default.
• W2019201831 creator A5026710321 @default.
• W2019201831 creator A5084573339 @default.
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• W2019201831 date "2011-09-01" @default.
• W2019201831 modified "2023-09-26" @default.
• W2019201831 title "Influence of Klotho genotypes on plasma NOx levels in South Indian population" @default.
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• W2019201831 doi "https://doi.org/10.1016/j.thromres.2011.04.002" @default.
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