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• W2019202457 endingPage "1782" @default.
• W2019202457 startingPage "1768" @default.
• W2019202457 abstract "In the last few years, accumulating evidence has shown the existence of an important cross-talk between adenosine A 2A receptors (A 2A Rs) and brain-derived neurotrophic factor (BDNF). Not only are A 2A Rs involved in the mechanism of transactivation of BDNF receptor TrkB, they also modulate the effect of BDNF on synaptic transmission, playing a facilitatory and permissive role. The cAMP-PKA pathway, the main transduction system operated by A 2A Rs, is involved in such effects. Furthermore, a basal tonus of A 2A Rs is required to allow the regulation of BDNF physiological levels in the brain, as demonstrated by the reduced protein levels measured in A 2A Rs KO mice. The crucial role of adenosine A 2A Rs in the maintenance of synaptic functions and BDNF levels will be reviewed here and discussed in the light of possible implications for Huntington's disease therapy, in which a joint impairment of BDNF and A 2A Rs seems to play a pathogenetic role." @default.
• W2019202457 created "2016-06-24" @default.
• W2019202457 creator A5012134128 @default.
• W2019202457 creator A5016686416 @default.
• W2019202457 creator A5022374002 @default.
• W2019202457 creator A5039881830 @default.
• W2019202457 creator A5059787908 @default.
• W2019202457 date "2010-01-01" @default.
• W2019202457 modified "2023-09-27" @default.
• W2019202457 title "Role of Adenosine A_2AReceptors in Modulating Synaptic Functions and Brain Levels of BDNF: a Possible Key Mechanism in the Pathophysiology of Huntington's Disease" @default.
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