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- W2019222399 abstract "The rat preprotachykinin-A promoter, which is able to direct reporter gene expression in adult dorsal root ganglia neurons grown in culture, has no detectable activity in HeLa and PC12 cells. DNAase 1 footprinting and electrophoretic mobility shift analyses with HeLa nuclear extract indicated the presence of a protein complex binding to a region of the rat preprotachykinn-A gene promoter between the TATA box and the major transcriptional start site. We demonstrate that the sequence of the preprotachykinin-A promoter spanning nucleotides -47 to +92 functions to repress reporter gene expression in HeLa and PC12 cells but not in adult rat dorsal root ganglia grown in culture, and that this repression is correlated with a protein(s) binding to the element between the TATA box and major transcription initiation site. These results indicate that the tissue-specific expression of the preprotachykinin-A gene could require the interaction of both positive and negative regulatory DNA elements." @default.
- W2019222399 created "2016-06-24" @default.
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- W2019222399 date "1995-04-01" @default.
- W2019222399 modified "2023-09-27" @default.
- W2019222399 title "Repression of preprotachykinin-A promoter activity is mediated by a proximal promoter element" @default.
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- W2019222399 doi "https://doi.org/10.1016/0306-4522(94)00554-i" @default.
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