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- W2019231344 abstract "Abstract The unopposed continuous administration of biologically active estrogenic materials produces a wide variety of cancers in experimental animals. Most of these cancers occur in the target tissues for estrogenic activity and appear to be characteristic of the animal rather than the estrogens. In mice and rats the most commonly induced tumor is breast cancer, followed by pituitary chromophobe adenoma, bladder cancer, tumors of the lymphatic system, adrenal tumors, etc. The characteristic tumor occurring in the hamster under these circumstances is clear cell cancer of the kidney. The dog appears to be an exception in that the continuous administration of estrogenic materials does not lead to such tumors but the administration of certain progestogens leads to the production of mammary tumors. Cancers of the cervix occur largely in mice while cancers of the uterine corpus are seen in rabbits. Laboratory primates appear to be remarkably resistant to the carcinogenic effect of steroids, either individually or in combination. In man, there is the suggestion that androgens given for long periods to stimulate erythropoiesis or oral contraceptives in combination with estrogen may be capable of producing benign hepatomas. In man there is also the suggestion that continuous administration of estrogen may produce adenocarcinoma of the corpus uteri and that women who are exposed to very high doses of synthetic estrogen during their intrauterine development have subsequently developed both benign adenosis and clear cell cancer of the vagina." @default.
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- W2019231344 date "1975-03-01" @default.
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- W2019231344 title "Steroids and carcinogenesis" @default.
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- W2019231344 doi "https://doi.org/10.1016/0022-4731(75)90127-2" @default.
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