Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019232743> ?p ?o ?g. }
- W2019232743 endingPage "1802" @default.
- W2019232743 startingPage "1793" @default.
- W2019232743 abstract "The degradation of cefaclor (1), an oral cephalosporin antibiotic, was studied at 37° in a neutral aqueous medium by HPLC and 1H-NMR. Under these conditions, 1 underwent intramolecular aminolysis by the 7-side-chain NH2 group on the β-lactam moiety to give a piperazine-2,5-dione. The most prominent peak in the HPLC profile of a degradation solution from 1 was isolated by prep. HPLC. Mechanistically, the formation of this degradation product cis-11 from 1 involves the contraction from a six-membered cephem ring to a five-membered ring, which presumably takes place via a common episulfonium ion intermediate 9 (see Scheme). Loss of the Cl-atom from 3-chloro-3-cephem is a general reaction subsequent to β-lactam ring opening." @default.
- W2019232743 created "2016-06-24" @default.
- W2019232743 creator A5018054556 @default.
- W2019232743 creator A5030801224 @default.
- W2019232743 creator A5048601132 @default.
- W2019232743 creator A5079687713 @default.
- W2019232743 date "1996-10-30" @default.
- W2019232743 modified "2023-10-17" @default.
- W2019232743 title "The Degradation Mechanism of an Oral Cephalosporin: Cefaclor" @default.
- W2019232743 cites W1772093770 @default.
- W2019232743 cites W1976037784 @default.
- W2019232743 cites W1976409201 @default.
- W2019232743 cites W1977209051 @default.
- W2019232743 cites W1982592302 @default.
- W2019232743 cites W1984515631 @default.
- W2019232743 cites W1986340877 @default.
- W2019232743 cites W1991818292 @default.
- W2019232743 cites W2004655680 @default.
- W2019232743 cites W2006370393 @default.
- W2019232743 cites W2011136408 @default.
- W2019232743 cites W2017889372 @default.
- W2019232743 cites W2026479462 @default.
- W2019232743 cites W2033838562 @default.
- W2019232743 cites W2039740654 @default.
- W2019232743 cites W2039934186 @default.
- W2019232743 cites W2041397825 @default.
- W2019232743 cites W2042640333 @default.
- W2019232743 cites W2048247316 @default.
- W2019232743 cites W2056110856 @default.
- W2019232743 cites W2058010086 @default.
- W2019232743 cites W2085105899 @default.
- W2019232743 cites W2089034067 @default.
- W2019232743 cites W2333178586 @default.
- W2019232743 cites W4229558063 @default.
- W2019232743 cites W4232546344 @default.
- W2019232743 cites W4240309139 @default.
- W2019232743 doi "https://doi.org/10.1002/hlca.19960790705" @default.
- W2019232743 hasPublicationYear "1996" @default.
- W2019232743 type Work @default.
- W2019232743 sameAs 2019232743 @default.
- W2019232743 citedByCount "9" @default.
- W2019232743 countsByYear W20192327432012 @default.
- W2019232743 countsByYear W20192327432014 @default.
- W2019232743 countsByYear W20192327432018 @default.
- W2019232743 countsByYear W20192327432020 @default.
- W2019232743 crossrefType "journal-article" @default.
- W2019232743 hasAuthorship W2019232743A5018054556 @default.
- W2019232743 hasAuthorship W2019232743A5030801224 @default.
- W2019232743 hasAuthorship W2019232743A5048601132 @default.
- W2019232743 hasAuthorship W2019232743A5079687713 @default.
- W2019232743 hasConcept C155647269 @default.
- W2019232743 hasConcept C161790260 @default.
- W2019232743 hasConcept C178790620 @default.
- W2019232743 hasConcept C179998833 @default.
- W2019232743 hasConcept C185592680 @default.
- W2019232743 hasConcept C2776131168 @default.
- W2019232743 hasConcept C2776201271 @default.
- W2019232743 hasConcept C2776368647 @default.
- W2019232743 hasConcept C2776568683 @default.
- W2019232743 hasConcept C2777998946 @default.
- W2019232743 hasConcept C2779074116 @default.
- W2019232743 hasConcept C2779679103 @default.
- W2019232743 hasConcept C2779766023 @default.
- W2019232743 hasConcept C2780378348 @default.
- W2019232743 hasConcept C2993420144 @default.
- W2019232743 hasConcept C41008148 @default.
- W2019232743 hasConcept C501593827 @default.
- W2019232743 hasConcept C55493867 @default.
- W2019232743 hasConcept C64778159 @default.
- W2019232743 hasConcept C71240020 @default.
- W2019232743 hasConcept C75079739 @default.
- W2019232743 hasConcept C76155785 @default.
- W2019232743 hasConceptScore W2019232743C155647269 @default.
- W2019232743 hasConceptScore W2019232743C161790260 @default.
- W2019232743 hasConceptScore W2019232743C178790620 @default.
- W2019232743 hasConceptScore W2019232743C179998833 @default.
- W2019232743 hasConceptScore W2019232743C185592680 @default.
- W2019232743 hasConceptScore W2019232743C2776131168 @default.
- W2019232743 hasConceptScore W2019232743C2776201271 @default.
- W2019232743 hasConceptScore W2019232743C2776368647 @default.
- W2019232743 hasConceptScore W2019232743C2776568683 @default.
- W2019232743 hasConceptScore W2019232743C2777998946 @default.
- W2019232743 hasConceptScore W2019232743C2779074116 @default.
- W2019232743 hasConceptScore W2019232743C2779679103 @default.
- W2019232743 hasConceptScore W2019232743C2779766023 @default.
- W2019232743 hasConceptScore W2019232743C2780378348 @default.
- W2019232743 hasConceptScore W2019232743C2993420144 @default.
- W2019232743 hasConceptScore W2019232743C41008148 @default.
- W2019232743 hasConceptScore W2019232743C501593827 @default.
- W2019232743 hasConceptScore W2019232743C55493867 @default.
- W2019232743 hasConceptScore W2019232743C64778159 @default.
- W2019232743 hasConceptScore W2019232743C71240020 @default.
- W2019232743 hasConceptScore W2019232743C75079739 @default.
- W2019232743 hasConceptScore W2019232743C76155785 @default.
- W2019232743 hasIssue "7" @default.
- W2019232743 hasLocation W20192327431 @default.
- W2019232743 hasOpenAccess W2019232743 @default.
- W2019232743 hasPrimaryLocation W20192327431 @default.