Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019240070> ?p ?o ?g. }
- W2019240070 endingPage "e23699" @default.
- W2019240070 startingPage "e23699" @default.
- W2019240070 abstract "We have completed a phase 1 safety and immunogenicity trial with hepatitis C virus (HCV) envelope glycoproteins, E1 and E2, with MF59 adjuvant as a candidate vaccine. Neutralizing activity to HCV genotype 1a was detected in approximately 25% of the vaccinee sera. In this study, we evaluated vaccinee sera from poor responders as a potential source of antibody dependent enhancement (ADE) of HCV infection. Sera with poor neutralizing activity enhanced cell culture grown HCV genotype 1a or 2a, and surrogate VSV/HCV pseudotype infection titer, in a dilution dependent manner. Surrogate pseudotypes generated from individual HCV glycoproteins suggested that antibody to the E2 glycoprotein; but not the E1 glycoprotein, was the principle target for enhancing infection. Antibody specific to FcRII expressed on the hepatic cell surface or to the Fc portion of Ig blocked enhancement of HCV infection by vaccinee sera. Together, the results from in vitro studies suggested that enhancement of viral infectivity may occur in the absence of a strong antibody response to HCV envelope glycoproteins." @default.
- W2019240070 created "2016-06-24" @default.
- W2019240070 creator A5013965950 @default.
- W2019240070 creator A5036112915 @default.
- W2019240070 creator A5039232082 @default.
- W2019240070 creator A5050529093 @default.
- W2019240070 creator A5078714130 @default.
- W2019240070 date "2011-08-22" @default.
- W2019240070 modified "2023-09-23" @default.
- W2019240070 title "A Weak Neutralizing Antibody Response to Hepatitis C Virus Envelope Glycoprotein Enhances Virus Infection" @default.
- W2019240070 cites W146287709 @default.
- W2019240070 cites W1827178381 @default.
- W2019240070 cites W1963707175 @default.
- W2019240070 cites W1963905773 @default.
- W2019240070 cites W1972097918 @default.
- W2019240070 cites W1975564745 @default.
- W2019240070 cites W1983245984 @default.
- W2019240070 cites W2001467294 @default.
- W2019240070 cites W2030986627 @default.
- W2019240070 cites W2045043196 @default.
- W2019240070 cites W2047619471 @default.
- W2019240070 cites W2052669763 @default.
- W2019240070 cites W2057822166 @default.
- W2019240070 cites W2060405418 @default.
- W2019240070 cites W2064526034 @default.
- W2019240070 cites W2064983946 @default.
- W2019240070 cites W2065438692 @default.
- W2019240070 cites W2066558535 @default.
- W2019240070 cites W2075147482 @default.
- W2019240070 cites W2081165230 @default.
- W2019240070 cites W2082157017 @default.
- W2019240070 cites W2083811968 @default.
- W2019240070 cites W2084534408 @default.
- W2019240070 cites W2096410933 @default.
- W2019240070 cites W2100166387 @default.
- W2019240070 cites W2103135474 @default.
- W2019240070 cites W2103803598 @default.
- W2019240070 cites W2110590116 @default.
- W2019240070 cites W2110628545 @default.
- W2019240070 cites W2118320694 @default.
- W2019240070 cites W2118873279 @default.
- W2019240070 cites W2121476095 @default.
- W2019240070 cites W2127896903 @default.
- W2019240070 cites W2133920480 @default.
- W2019240070 cites W2150244847 @default.
- W2019240070 cites W2153646511 @default.
- W2019240070 cites W2153919911 @default.
- W2019240070 cites W2154791057 @default.
- W2019240070 cites W2160174559 @default.
- W2019240070 cites W2160608290 @default.
- W2019240070 cites W2168597289 @default.
- W2019240070 cites W2325310573 @default.
- W2019240070 doi "https://doi.org/10.1371/journal.pone.0023699" @default.
- W2019240070 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3161815" @default.
- W2019240070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21887300" @default.
- W2019240070 hasPublicationYear "2011" @default.
- W2019240070 type Work @default.
- W2019240070 sameAs 2019240070 @default.
- W2019240070 citedByCount "24" @default.
- W2019240070 countsByYear W20192400702012 @default.
- W2019240070 countsByYear W20192400702013 @default.
- W2019240070 countsByYear W20192400702014 @default.
- W2019240070 countsByYear W20192400702015 @default.
- W2019240070 countsByYear W20192400702016 @default.
- W2019240070 countsByYear W20192400702017 @default.
- W2019240070 countsByYear W20192400702018 @default.
- W2019240070 countsByYear W20192400702020 @default.
- W2019240070 countsByYear W20192400702021 @default.
- W2019240070 crossrefType "journal-article" @default.
- W2019240070 hasAuthorship W2019240070A5013965950 @default.
- W2019240070 hasAuthorship W2019240070A5036112915 @default.
- W2019240070 hasAuthorship W2019240070A5039232082 @default.
- W2019240070 hasAuthorship W2019240070A5050529093 @default.
- W2019240070 hasAuthorship W2019240070A5078714130 @default.
- W2019240070 hasBestOaLocation W20192400701 @default.
- W2019240070 hasConcept C106358424 @default.
- W2019240070 hasConcept C108625454 @default.
- W2019240070 hasConcept C153911025 @default.
- W2019240070 hasConcept C159047783 @default.
- W2019240070 hasConcept C159654299 @default.
- W2019240070 hasConcept C203014093 @default.
- W2019240070 hasConcept C22070199 @default.
- W2019240070 hasConcept C2522874641 @default.
- W2019240070 hasConcept C2776408679 @default.
- W2019240070 hasConcept C2779261636 @default.
- W2019240070 hasConcept C2780868878 @default.
- W2019240070 hasConcept C2781463415 @default.
- W2019240070 hasConcept C32611913 @default.
- W2019240070 hasConcept C71924100 @default.
- W2019240070 hasConcept C86803240 @default.
- W2019240070 hasConceptScore W2019240070C106358424 @default.
- W2019240070 hasConceptScore W2019240070C108625454 @default.
- W2019240070 hasConceptScore W2019240070C153911025 @default.
- W2019240070 hasConceptScore W2019240070C159047783 @default.
- W2019240070 hasConceptScore W2019240070C159654299 @default.
- W2019240070 hasConceptScore W2019240070C203014093 @default.
- W2019240070 hasConceptScore W2019240070C22070199 @default.
- W2019240070 hasConceptScore W2019240070C2522874641 @default.