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• W2019241796 abstract "Poststroke depression (PSD) leads to impaired functional recovery and increased mortality, yet physiological mechanisms are unknown. The present study investigates the roles of glucocorticoids and interleukin-1 (IL-1) in poststroke anhedonia.Adult male mice underwent middle cerebral artery occlusion (MCAO), and were recovered 7 days. Mice were treated with metyrapone (100 mg/kg intraperitoneally), mifepristone (50 mg/kg subcutaneously), or vehicle injections on reperfusion days 4-7. A separate cohort of mice was implanted with cannulae and was administered IL-1 receptor antagonist (IL-1ra) or vehicle (6 microg intracerebroventricularly) on reperfusion days 6 and 7. After the final injection or infusion, sucrose consumption was recorded for 6 hours.Mice in the sham-treated group consumed significantly more sucrose solution than water, whereas MCAO-treated mice consumed similar amounts of each, suggesting anhedonia among MCAO-treated mice. A separate experiment assessed whether stroke-induced increases in corticosteroids or IL-1 contribute to anhedonia. Only IL-1ra restored sucrose consumption in MCAO-treated mice. Vehicle-MCAO-treated mice drank significantly less sucrose solution than did both IL-1ra and vehicle-sham treatment groups, whereas IL-1ra-MCAO-treated mice drank similar amounts to both sham-treated groups.Poststroke anhedonia, a symptom of depression in human beings, can be reproduced in a mouse model of stroke and appears to involve altered IL-1 transmission in the brain." @default.
• W2019241796 created "2016-06-24" @default.
• W2019241796 creator A5051052153 @default.
• W2019241796 creator A5091590767 @default.
• W2019241796 date "2006-10-01" @default.
• W2019241796 modified "2023-09-27" @default.
• W2019241796 title "Role of IL-1 in Poststroke Depressive-like Behavior in Mice" @default.
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• W2019241796 doi "https://doi.org/10.1016/j.biopsych.2006.03.011" @default.
• W2019241796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16730336" @default.
• W2019241796 hasPublicationYear "2006" @default.
• W2019241796 type Work @default.
• W2019241796 sameAs 2019241796 @default.

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