FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019247704> ?p ?o ?g. }

• W2019247704 endingPage "955" @default.
• W2019247704 startingPage "949" @default.
• W2019247704 abstract "In the present study, Herceptin was labeled with lutetium-177 via DOTA, and the necessary preclinical quality control tests (in vitro and in vivo) were performed to evaluate its use as a radioimmunotherapy agent. Herceptin was conjugated to DOTA as a chelator in three different conjugation buffers (ammonium acetate, carbonate and HEPES buffer); each of the resulting conjugates was compared with respect to in vitro characteristics such as number of chelates per antibody, incorporated activity, immunoreactivity and in vitro stability in PBS buffer and blood serum. The biodistribution study and gamma camera imaging were performed in mice bearing breast tumors. To assess the therapeutic effects of 177Lu-Herceptin, cytotoxicity was investigated for 7 days in a SKBr3 breast cancer cell line. Carbonate buffer was the best conjugation buffer (number of chelates per antibody: 6; incorporated activity: 81%; immunoreactivity: 87%; buffer stability: 86%; serum stability: 81%, after 4 days). The efficient tumor uptake observed in the biodistribution studies was consistent with the gamma camera image results. At a concentration of 4 μg ml−1, 177Lu-Herceptin (surviving cells: 5±0.6% of the total cells) of the total cells corresponded to an approximately eightfold increase in cytotoxicity in comparison to unmodified Herceptin (surviving cells: 43±3.9%). The new complex described herein could be considered for further evaluation in animals and potentially in humans as a radiopharmaceutical for use in the radioimmunotherapy of breast cancer. These results may be important for patients who cannot tolerate the therapeutic dosage of Herceptin currently used because of heart problems." @default.
• W2019247704 created "2016-06-24" @default.
• W2019247704 creator A5000450348 @default.
• W2019247704 creator A5033655602 @default.
• W2019247704 creator A5060653118 @default.
• W2019247704 creator A5088287905 @default.
• W2019247704 date "2010-11-01" @default.
• W2019247704 modified "2023-10-01" @default.
• W2019247704 title "177Lu labeling of Herceptin and preclinical validation as a new radiopharmaceutical for radioimmunotherapy of breast cancer" @default.
• W2019247704 cites W1755131301 @default.
• W2019247704 cites W1775749144 @default.
• W2019247704 cites W197699128 @default.
• W2019247704 cites W1991554959 @default.
• W2019247704 cites W1997285329 @default.
• W2019247704 cites W2003403455 @default.
• W2019247704 cites W2017553488 @default.
• W2019247704 cites W2019492358 @default.
• W2019247704 cites W2027985916 @default.
• W2019247704 cites W2030106014 @default.
• W2019247704 cites W2032610835 @default.
• W2019247704 cites W2058426435 @default.
• W2019247704 cites W2078500408 @default.
• W2019247704 cites W2083666292 @default.
• W2019247704 cites W2083793124 @default.
• W2019247704 cites W2089487481 @default.
• W2019247704 cites W2114918609 @default.
• W2019247704 cites W2140594839 @default.
• W2019247704 cites W2141917836 @default.
• W2019247704 cites W2159636814 @default.
• W2019247704 cites W4239462698 @default.
• W2019247704 doi "https://doi.org/10.1016/j.nucmedbio.2010.07.001" @default.
• W2019247704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21055626" @default.
• W2019247704 hasPublicationYear "2010" @default.
• W2019247704 type Work @default.
• W2019247704 sameAs 2019247704 @default.
• W2019247704 citedByCount "37" @default.
• W2019247704 countsByYear W20192477042012 @default.
• W2019247704 countsByYear W20192477042013 @default.
• W2019247704 countsByYear W20192477042014 @default.
• W2019247704 countsByYear W20192477042015 @default.
• W2019247704 countsByYear W20192477042016 @default.
• W2019247704 countsByYear W20192477042017 @default.
• W2019247704 countsByYear W20192477042018 @default.
• W2019247704 countsByYear W20192477042019 @default.
• W2019247704 countsByYear W20192477042020 @default.
• W2019247704 countsByYear W20192477042021 @default.
• W2019247704 countsByYear W20192477042022 @default.
• W2019247704 countsByYear W20192477042023 @default.
• W2019247704 crossrefType "journal-article" @default.
• W2019247704 hasAuthorship W2019247704A5000450348 @default.
• W2019247704 hasAuthorship W2019247704A5033655602 @default.
• W2019247704 hasAuthorship W2019247704A5060653118 @default.
• W2019247704 hasAuthorship W2019247704A5088287905 @default.
• W2019247704 hasConcept C109316439 @default.
• W2019247704 hasConcept C121608353 @default.
• W2019247704 hasConcept C126322002 @default.
• W2019247704 hasConcept C150903083 @default.
• W2019247704 hasConcept C159654299 @default.
• W2019247704 hasConcept C178790620 @default.
• W2019247704 hasConcept C185592680 @default.
• W2019247704 hasConcept C191560914 @default.
• W2019247704 hasConcept C197404232 @default.
• W2019247704 hasConcept C202751555 @default.
• W2019247704 hasConcept C203014093 @default.
• W2019247704 hasConcept C207001950 @default.
• W2019247704 hasConcept C2776146153 @default.
• W2019247704 hasConcept C2777807558 @default.
• W2019247704 hasConcept C2779931791 @default.
• W2019247704 hasConcept C2994423619 @default.
• W2019247704 hasConcept C502942594 @default.
• W2019247704 hasConcept C530470458 @default.
• W2019247704 hasConcept C542903549 @default.
• W2019247704 hasConcept C55493867 @default.
• W2019247704 hasConcept C71924100 @default.
• W2019247704 hasConcept C86803240 @default.
• W2019247704 hasConcept C98274493 @default.
• W2019247704 hasConceptScore W2019247704C109316439 @default.
• W2019247704 hasConceptScore W2019247704C121608353 @default.
• W2019247704 hasConceptScore W2019247704C126322002 @default.
• W2019247704 hasConceptScore W2019247704C150903083 @default.
• W2019247704 hasConceptScore W2019247704C159654299 @default.
• W2019247704 hasConceptScore W2019247704C178790620 @default.
• W2019247704 hasConceptScore W2019247704C185592680 @default.
• W2019247704 hasConceptScore W2019247704C191560914 @default.
• W2019247704 hasConceptScore W2019247704C197404232 @default.
• W2019247704 hasConceptScore W2019247704C202751555 @default.
• W2019247704 hasConceptScore W2019247704C203014093 @default.
• W2019247704 hasConceptScore W2019247704C207001950 @default.
• W2019247704 hasConceptScore W2019247704C2776146153 @default.
• W2019247704 hasConceptScore W2019247704C2777807558 @default.
• W2019247704 hasConceptScore W2019247704C2779931791 @default.
• W2019247704 hasConceptScore W2019247704C2994423619 @default.
• W2019247704 hasConceptScore W2019247704C502942594 @default.
• W2019247704 hasConceptScore W2019247704C530470458 @default.
• W2019247704 hasConceptScore W2019247704C542903549 @default.
• W2019247704 hasConceptScore W2019247704C55493867 @default.
• W2019247704 hasConceptScore W2019247704C71924100 @default.
• W2019247704 hasConceptScore W2019247704C86803240 @default.

• next