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- W2019250178 abstract "Abstract 1. 1. The mechanism of the double transamidination leading to the biosynthesis of arcaine (1.4-diamidinoputrescine) and of hirudonine (1.7-diamidinospermidine) has been investigated in vivo in the leech, Hirudo medicinalis L. 2. 2. For both compounds, the transsmidination reaction proceeds in two steps and involves the intermediate formation of a monoamidinated derivative, namely agmatine in the case of arcaine and monoamidinospermidine in that of hirudonine. 3. 3. The monoamidinated derivative of spermidine synthesized as an intermediate metabolite in the biogenesis of hirudonine has been identified as N-(3-guanidinopropyl) 1.4-diaminobutane. The localization of the amidine group of that compound on the propylamine moiety has been established by chemical degradation of hirudonine and of monoamidinospermidine isolated from the leeches injected with the suitable labeled precursors. 4. 4. Amidinotransferase specificity towards that derivative is not absolute. The enzyme also acts on the monoamidinospermidine carrying the amidine group on the butylamine moiety, N-(4-guanidinobutyl) 1.3-diaminopropane." @default.
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- W2019250178 date "1967-09-01" @default.
- W2019250178 modified "2023-10-09" @default.
- W2019250178 title "Biogenese des derives diguanidiques chez la sangsue, Hirudo medicinalis L.—II. Mecanisme de la double transamidination" @default.
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- W2019250178 doi "https://doi.org/10.1016/0010-406x(67)90771-2" @default.
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