SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019258251> ?p ?o ?g. }

Showing items 1 to 100 of ±106 with 100 items per page.

W2019258251 endingPage "465" @default.
W2019258251 startingPage "462" @default.
W2019258251 abstract "We have developed an efficient expression cloning system that allows rapid isolation of complementary DNAs able to induce the transformed phenotype. We searched for molecules expressed in epithelial cells and possessing transforming potential to fibroblasts, and cloned a cDNA for the normal receptor of a growth factor secreted by NIH/3T3 cells. Here we report a second novel transforming gene, ect2. The isolated cDNA is activated by amino-terminal truncation of the normal product. The Ect2 protein has sequence similarity within a central core of 255 amino acids with the products of the breakpoint cluster gene, bcr (ref. 5), the yeast cell cycle gene, CDC24 (ref. 6), and the dbl oncogene. Each of these genes encodes regulatory molecules or effectors for Rho-like small GTP-binding proteins. The baculovirus-expressed Ect2 protein could bind highly specifically to Rho and Rac proteins, whereas the dbl product showed broader binding specificity to Rho family proteins. Thus ect2 is a new member of an expanding family, whose products have transforming properties and interact with Rho-like proteins of the Ras superfamily." @default.
W2019258251 created "2016-06-24" @default.
W2019258251 creator A5005115402 @default.
W2019258251 creator A5008456176 @default.
W2019258251 creator A5044410528 @default.
W2019258251 creator A5067914650 @default.
W2019258251 creator A5070456684 @default.
W2019258251 date "1993-04-01" @default.
W2019258251 modified "2023-10-04" @default.
W2019258251 title "Oncogene ect2 is related to regulators of small GTP-binding proteins" @default.
W2019258251 cites W1559869116 @default.
W2019258251 cites W1766782882 @default.
W2019258251 cites W1873199501 @default.
W2019258251 cites W1937507172 @default.
W2019258251 cites W1981012177 @default.
W2019258251 cites W1984875233 @default.
W2019258251 cites W1993972454 @default.
W2019258251 cites W1994139415 @default.
W2019258251 cites W1995889524 @default.
W2019258251 cites W2000615970 @default.
W2019258251 cites W2011751979 @default.
W2019258251 cites W2034200430 @default.
W2019258251 cites W2045561594 @default.
W2019258251 cites W2050719006 @default.
W2019258251 cites W2068446924 @default.
W2019258251 cites W2074641624 @default.
W2019258251 cites W2085193833 @default.
W2019258251 cites W2088775512 @default.
W2019258251 cites W2091349362 @default.
W2019258251 cites W2092727362 @default.
W2019258251 cites W2158726454 @default.
W2019258251 cites W2159137674 @default.
W2019258251 cites W2169358645 @default.
W2019258251 cites W4252217633 @default.
W2019258251 doi "https://doi.org/10.1038/362462a0" @default.
W2019258251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8464478" @default.
W2019258251 hasPublicationYear "1993" @default.
W2019258251 type Work @default.
W2019258251 sameAs 2019258251 @default.
W2019258251 citedByCount "266" @default.
W2019258251 countsByYear W20192582512012 @default.
W2019258251 countsByYear W20192582512013 @default.
W2019258251 countsByYear W20192582512014 @default.
W2019258251 countsByYear W20192582512015 @default.
W2019258251 countsByYear W20192582512016 @default.
W2019258251 countsByYear W20192582512017 @default.
W2019258251 countsByYear W20192582512018 @default.
W2019258251 countsByYear W20192582512019 @default.
W2019258251 countsByYear W20192582512020 @default.
W2019258251 countsByYear W20192582512021 @default.
W2019258251 countsByYear W20192582512022 @default.
W2019258251 countsByYear W20192582512023 @default.
W2019258251 crossrefType "journal-article" @default.
W2019258251 hasAuthorship W2019258251A5005115402 @default.
W2019258251 hasAuthorship W2019258251A5008456176 @default.
W2019258251 hasAuthorship W2019258251A5044410528 @default.
W2019258251 hasAuthorship W2019258251A5067914650 @default.
W2019258251 hasAuthorship W2019258251A5070456684 @default.
W2019258251 hasBestOaLocation W20192582512 @default.
W2019258251 hasConcept C104317684 @default.
W2019258251 hasConcept C118716 @default.
W2019258251 hasConcept C150194340 @default.
W2019258251 hasConcept C153911025 @default.
W2019258251 hasConcept C181199279 @default.
W2019258251 hasConcept C187882448 @default.
W2019258251 hasConcept C195286587 @default.
W2019258251 hasConcept C2781335528 @default.
W2019258251 hasConcept C54355233 @default.
W2019258251 hasConcept C55493867 @default.
W2019258251 hasConcept C86803240 @default.
W2019258251 hasConcept C95444343 @default.
W2019258251 hasConceptScore W2019258251C104317684 @default.
W2019258251 hasConceptScore W2019258251C118716 @default.
W2019258251 hasConceptScore W2019258251C150194340 @default.
W2019258251 hasConceptScore W2019258251C153911025 @default.
W2019258251 hasConceptScore W2019258251C181199279 @default.
W2019258251 hasConceptScore W2019258251C187882448 @default.
W2019258251 hasConceptScore W2019258251C195286587 @default.
W2019258251 hasConceptScore W2019258251C2781335528 @default.
W2019258251 hasConceptScore W2019258251C54355233 @default.
W2019258251 hasConceptScore W2019258251C55493867 @default.
W2019258251 hasConceptScore W2019258251C86803240 @default.
W2019258251 hasConceptScore W2019258251C95444343 @default.
W2019258251 hasIssue "6419" @default.
W2019258251 hasLocation W20192582511 @default.
W2019258251 hasLocation W20192582512 @default.
W2019258251 hasLocation W20192582513 @default.
W2019258251 hasOpenAccess W2019258251 @default.
W2019258251 hasPrimaryLocation W20192582511 @default.
W2019258251 hasRelatedWork W1530716184 @default.
W2019258251 hasRelatedWork W1531528770 @default.
W2019258251 hasRelatedWork W2009966535 @default.
W2019258251 hasRelatedWork W2049946166 @default.
W2019258251 hasRelatedWork W2355709092 @default.
W2019258251 hasRelatedWork W2365238423 @default.
W2019258251 hasRelatedWork W2375466314 @default.
W2019258251 hasRelatedWork W2383598698 @default.
W2019258251 hasRelatedWork W2432838036 @default.