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- W2019260043 abstract "<h3>Importance</h3> Reversible cerebral vasoconstriction syndrome (RCVS) is a clinical-angiographic syndrome characterized by recurrent thunderclap headaches and reversible segmental multifocal cerebral artery narrowing. More than 30% of patients with RCVS develop subarachnoid hemorrhage (SAH). Patients with RCVS with SAH (RCVS-SAH) are often misdiagnosed as having potentially ominous conditions such as aneurysmal SAH (aSAH) or cryptogenic “angiogram-negative” SAH (cSAH) owing to overlapping clinical and imaging features. <h3>Objective</h3> To identify predictors that can distinguish RCVS-SAH from aSAH and cSAH at the time of clinical presentation. <h3>Design</h3> Retrospective analysis of 3 patient cohorts: patients with RCVS (1998-2009), patients with aSAH (1995-2003), and patients with cSAH (1995-2003). <h3>Setting</h3> Academic hospital and tertiary referral center. <h3>Participants</h3> Consecutive patients with RCVS-SAH (n = 38), aSAH (n = 515), or cSAH (n = 93) whose conditions were diagnosed using standard criteria. <h3>Main Outcomes and Measures</h3> Multivariate logistic regression analysis was used to identify predictors that differentiate RCVS-SAH from aSAH and cSAH. <h3>Results</h3> Predictors differentiating RCVS-SAH from aSAH were younger age, chronic headache disorder, prior depression, prior chronic obstructive pulmonary disease, lower Hunt-Hess grade, lower Fisher SAH group, higher number of affected arteries, and the presence of bilateral arterial narrowing. Predictors differentiating RCVS-SAH from cSAH were younger age, female sex, prior hypertension, chronic headache disorder, lower Hunt-Hess grade, lower Fisher SAH group, and the presence of bilateral arterial narrowing. <h3>Conclusions and Relevance</h3> We identified important clinical and imaging differences between RCVS-SAH, aSAH, and cSAH that may be useful for improving diagnostic accuracy, clinical management, and resource utilization." @default.
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- W2019260043 date "2013-08-12" @default.
- W2019260043 modified "2023-10-02" @default.
- W2019260043 title "Differentiating Reversible Cerebral Vasoconstriction Syndrome With Subarachnoid Hemorrhage From Other Causes of Subarachnoid Hemorrhage" @default.
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- W2019260043 doi "https://doi.org/10.1001/jamaneurol.2013.3484" @default.
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