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- W2019261076 abstract "Changes in regional V–Q ratios in response to various interventions have been evaluated using complex techniques. The purpose of this study was to develop a new and practical technique for accurately assessing changes in relative perfusion and ventilation in response to an intervention. For this purpose we have chosen to evaluate this method to access changes in V–Q values at rest and exercise. 18 male subjects underwent resting ventilation images using krypton-81 followed by perfusion images using 300 uCi of Tc-99m-MAA. All images contained 500,000 counts and were obtained in the posterior position. Using a cycle argometer, 80% of the maximal predicted heart rate was obtained and maintained for a 5− minute period. The subjects again breathed krypton, and an exercise ventilation image was obtained. This was immediately followed by a 3 mCi Tc-99m-MAA perfusion study. All information was acquired on computer using a 64x64 matrix. Positioning was kept constant by alignment of cobalt sources attached to the subject's back. The lung was trisected, allowing for regional analysis of V–Q ratios. This method was capable of demonstrating a significant increase in perfusion of upper lung zones in response to exercise. The resting perfusion to the right lung was significantly greater than the left, and during exercise there was a major trend to equalize perfusion between the two lungs. Ventilation increased over the right lung, resulting in a relatively higher V–Q ratio on the right than on the left. This method is simple to perform and analyze, and may have a role in determining the effects of therapeutic regimens in cardiovascular or pulmonary disease." @default.
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- W2019261076 date "1984-09-01" @default.
- W2019261076 modified "2023-09-26" @default.
- W2019261076 title "A METHOD FOR DETERMINING CHANGES IN V-Q RATIOS DUE TO INTERVENTION" @default.
- W2019261076 doi "https://doi.org/10.1097/00003072-198409001-00028" @default.
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